SCHEMBL28426470

SCHEMBL28426470

O=c1ccn(-n2ccc(=O)[nH]c2=O)c(=O)[nH]1

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 3/20 0.58
DDB1 Q16531 1/20 0.52
PKM P14618 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
DUT P33316 4/20 0.36
SLC28A1 O00337 1/20 0.36
SLC28A2 O43868 1/20 0.36
SLC29A1 Q99808 1/20 0.36
SLC28A3 Q9HAS3 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21183289 0.80 CRBN (0.45) CRBNDDB1PKML3MBTL1ALDH1A1
SCHEMBL10423652 0.79
SCHEMBL7157402 0.79 CRBN (0.44) CRBNDDB1PKMLMNADUT
SCHEMBL11623275 0.77 CRBN (0.42) CRBNDDB1PKML3MBTL1ALDH1A1
SCHEMBL710129 0.74
SCHEMBL21385228 0.74
SCHEMBL5963506 0.74
SCHEMBL8377720 0.74
SCHEMBL8790967 0.74
SCHEMBL35355 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111434652-B Diuracil, use thereof and method for producing same 科丝美诗株式会社 2023-05-26 CN disclosed
CN-111434652-A Novel bisuracil, its use and preparation method 科丝美诗株式会社 2020-07-21 CN disclosed