Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | MET | P08581 | 6/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | MST1R | Q04912 | 2/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.46 |
| ▸ | KIT | P10721 | 5/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28420947 | 0.90 | KDR (0.51) | PDE4DCSF1RPDGFRBFLT3KDR | |
| SCHEMBL29111067 | 0.85 | PDGFRA (0.58) | PDE4APDE4BPDE4CPDE4DKDR | |
| SCHEMBL28430848 | 0.84 | KDR (0.52) | PDE4DCSF1RPDGFRBFLT3KDR | |
| SCHEMBL28425279 | 0.83 | BRAF (0.50) | PDE4APDE4BPDE4CPDE4DKDR | |
| SCHEMBL25130570 | 0.80 | PDE4B (0.55) | PDE4APDE4BPDE4CPDE4DKDR | |
| SCHEMBL28834249 | 0.80 | PIK3CD (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29933502 | 0.80 | PIK3CD (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28834247 | 0.80 | PIK3CD (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5687602 | 0.78 | GPR119 (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24010678 | 0.78 | MET (0.54) | PDE4APDE4BPDE4CPDE4DMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111253385-B | Heterocyclic compound, preparation method and application | 遵义医科大学珠海校区 | 2023-11-24 | — | — | CN | disclosed |
| CN-111253385-A | Heterocyclic compound, preparation method and application | 遵义医科大学珠海校区 | 2020-06-09 | — | — | CN | disclosed |