Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.45 |
| ▸ | NQO2 | P16083 | 5/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.45 |
| ▸ | ESR1 | P03372 | 7/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.40 |
| ▸ | ESRRG | P62508 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247685 | 0.95 | SHBG (0.53) | SHBGPTGS1NQO2PTGS2ESR1 | |
| SCHEMBL18600 | 0.95 | SHBG (0.53) | SHBGPTGS1NQO2PTGS2ESR1 | |
| SCHEMBL26035535 | 0.90 | SHBG (0.47) | SHBGPTGS1NQO2PTGS2ESR1 | |
| SCHEMBL20414725 | 0.87 | SHBG (0.47) | SHBGPTGS1NQO2PTGS2ESR1 | |
| SCHEMBL6280436 | 0.80 | SHBG (0.38) | SHBGPTGS1NQO2PTGS2ESR1 | |
| SCHEMBL10631105 | 0.78 | TAAR1 (0.40) | SHBGESR1ESR2ESRRGCYP3A4 | |
| SCHEMBL10631111 | 0.78 | TAAR1 (0.40) | SHBGESR1ESR2ESRRGCYP3A4 | |
| SCHEMBL674805 | 0.74 | ESR1 (0.44) | PTGS1PTGS2ESR1ESR2ESRRG | |
| SCHEMBL674804 | 0.74 | ESR1 (0.44) | PTGS1PTGS2ESR1ESR2ESRRG | |
| SCHEMBL674803 | 0.74 | ESR1 (0.44) | PTGS1PTGS2ESR1ESR2ESRRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111148792-B | Impact modified styrene copolymer compositions containing polysiloxane additives with improved abrasion resistance | 英力士苯领集团股份公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-111247205-A | Impact modified styrenic copolymer compositions containing polysiloxane additives with improved abrasion resistance | 英力士苯领集团股份公司 | 2020-06-05 | — | — | CN | disclosed |
| CN-111148792-A | Impact modified styrenic copolymer compositions containing polysiloxane additives with improved abrasion resistance | 英力士苯领集团股份公司 | 2020-05-12 | — | — | CN | disclosed |