Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | GPR3 | P46089 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27877115 | 0.77 | GPR3 (0.39) | KIF11GPR3MAPTCHRM5CCR6 | |
| SCHEMBL6417992 | 0.76 | CA4 (0.44) | MAPTSMN1; SMN2 | |
| SCHEMBL4070737 | 0.75 | NOTUM (0.40) | KIF11GPR3MAPTACP1SERPINE1 | |
| SCHEMBL18293362 | 0.74 | KIF11 (0.50) | KIF11IGF2BP2GRIN2BCHRM5ACP1 | |
| SCHEMBL306823 | 0.74 | KIF11 (0.50) | KIF11IGF2BP2GRIN2BCHRM5ACP1 | |
| SCHEMBL8125229 | 0.74 | METAP2 (0.38) | METAP2KIF11GPR3IGF2BP2CHRM5 | |
| SCHEMBL28910204 | 0.72 | SERPINE1 (0.49) | KIF11IGF2BP2GRIN2BCHRM5ACP1 | |
| SCHEMBL28436016 | 0.72 | KIF11 (0.54) | METAP2KIF11KCNH2 | |
| SCHEMBL28961082 | 0.71 | LTA4H (0.48) | MAPTSMN1; SMN2 | |
| SCHEMBL621805 | 0.71 | GPR3 (0.38) | KIF11GPR3MAPTSMN1; SMN2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111087338-B | Sulfonamide-substituted pyrrolidones derivative and preparation method thereof | 常州大学 | 2021-03-02 | — | — | CN | claimed |
| CN-111087338-A | Sulfonamide-substituted pyrrolidones derivative and preparation method thereof | 常州大学 | 2020-05-01 | — | — | CN | claimed |
| CN-111087338-B | Sulfonamide-substituted pyrrolidones derivative and preparation method thereof | 常州大学 | 2021-03-02 | — | — | CN | disclosed |
| CN-111087338-A | Sulfonamide-substituted pyrrolidones derivative and preparation method thereof | 常州大学 | 2020-05-01 | — | — | CN | disclosed |