SCHEMBL284378

SCHEMBL284378

CCCCCCCC[Si](OC(C)C)(OC(C)C)C(C)C

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.35
TSHR P16473 1/20 0.35
THRB P10828 1/20 0.35
DNM1 Q05193 2/20 0.31
TRPM8 Q7Z2W7 4/20 0.30
OPRM1 P35372 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL704693 0.89
SCHEMBL702389 0.84
SCHEMBL27795145 0.82 TSHR (0.38) LMNATSHRTHRBDNM1TRPM8
SCHEMBL8953509 0.80 LMNA (0.38) LMNATSHRTHRBDNM1TRPM8
SCHEMBL20658098 0.79 LMNA (0.34) LMNATSHRTHRBDNM1TRPM8
SCHEMBL703368 0.78
SCHEMBL25299366 0.77 LMNA (0.39) LMNATSHRTHRBDNM1TRPM8
SCHEMBL191086 0.77 LMNA (0.39) LMNATSHRTHRBDNM1TRPM8
SCHEMBL25261552 0.77 LMNA (0.39) LMNATSHRTHRBDNM1TRPM8
SCHEMBL190922 0.77 LMNA (0.39) LMNATSHRTHRBDNM1TRPM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11642653-B2 Hybrid material for chromatographic separations comprising a superficially porous core and a surrounding material WATERS TECHNOLOGIES CORPORATION (US) 2023-05-09 US disclosed
US-9976008-B2 Porous inorganic/organic homogenous copolymeric hybrid materials for chromatographic separations and process for the preparation thereof WATERS TECHNOLOGIES CORPORATION (US) 2018-05-22 US disclosed
US-20170173561-A1 HYBRID MATERIAL FOR CHROMATOGRAPHIC SEPARATIONS COMPRISING A SUPERFICIALLY POROUS CORE AND A SURROUNDING MATERIAL WATERS TECHNOLOGIES CORPORATION 2017-06-22 US disclosed
US-20160184736-A1 CHROMATOGRAPHIC COLUMNS AND SEPARATION DEVICES COMPRISING A SUPERFICIALLY POROUS MATERIAL; AND USE THEREOF FOR SUPERCRITICAL FLUID CHROMATOGRAPHY AND OTHER CHROMATOGRAPHY WATERS TECHNOLOGIES CORPORATION (US) 2016-06-30 US disclosed
US-20160096943-A1 POROUS INORGANIC/ORGANIC HOMOGENOUS COPOLYMERIC HYBRID MATERIALS FOR CHROMATOGRAPHIC SEPARATIONS AND PROCESS FOR THE PREPARATION THEREOF WATERS TECHNOLOGIES CORPORATION 2016-04-07 US disclosed
US-20160008737-A1 POROUS INORGANIC/ORGANIC HYBRID MATERIALS WITH ORDERED DOMAINS FOR CHROMATOGRAPHIC SEPARATIONS AND PROCESSES FOR THEIR PREPARATION WATERS INVESTMENTS LIMITED 2016-01-14 US disclosed
US-20150367326-A1 POROUS INORGANIC/ORGANIC HYBRID PARTICLES HAVING HIGH ORGANIC CONTENT AND ENHANCED PORE GEOMETRY FOR CHROMATOGRAPHIC SEPARATIONS WATERS TECHNOLOGIES CORPORATION (US) 2015-12-24 US disclosed
US-9211524-B2 Porous inorganic/organic homogenous copolymeric hybrid materials for chromatographic separations and process for the preparation thereof WATERS TECHNOLOGIES CORPORATION (US) 2015-12-15 US disclosed
US-9145481-B2 Porous inorganic/organic hybrid materials with ordered domains for chromatographic separations and processes for their preparation WATERS TECHNOLOGIES CORPORATION (US) 2015-09-29 US disclosed
US-20140329919-A1 POROUS INORGANIC/ORGANIC HYBRID MATERIALS WITH ORDERED DOMAINS FOR CHROMATOGRAPHIC SEPARATIONS AND PROCESSES FOR THEIR PREPARATION WATERS TECHNOLOGIES CORPORATION (US) 2014-11-06 US disclosed
US-8791220-B2 Porous inorganic/organic homogenous copolymeric hybrid materials for chromatographic separation and process for the preparation thereof WATERS TECHNOLOGIES CORPORATION (US) 2014-07-29 US disclosed
US-20140194283-A1 POROUS INORGANIC/ORGANIC HOMOGENOUS COPOLYMERIC HYBRID MATERIALS FOR CHROMATOGRAPHIC SEPARATIONS AND PROCESS FOR THE PREPARATION THEREOF WATERS TECHNOLOGIES CORPORATION (US) 2014-07-10 US disclosed
US-8658277-B2 Porous inorganic/organic hybrid materials with ordered domains for chromatographic separations and processes for their preparation WATERS TECHNOLOGIES CORPORATION (US) 2014-02-25 US disclosed
US-20130206665-A1 SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS HYBRID CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS WATERS TECHNOLOGIES CORPORATION (US) 2013-08-15 US disclosed
US-20120055860-A1 HYBRID INORGANIC/ORGANIC MATERIALS HAVING NOVEL SURFACE MODIFICATION; PROCESS FOR THE PREPARATION OF INORGANIC/ORGANIC HYBRID MATERIALS; AND USE OF SAID PARTICLES FOR CHROMATOGRAPHIC SEPARATIONS WATERS TECHNOLOGIES CORPORATION (US) 2012-03-08 US disclosed
US-20090209722-A1 POROUS INORGANIC/ORGANIC HOMOGENOUS COPOLYMERIC HYBRID MATERIALS FOR CHROMATOGRAPHIC SEPARATION AND PROCESS FOR THE PREPARATION THEREOF WATERS INVESTMENTS LIMITED (US) 2009-08-20 US disclosed
US-20080269368-A1 addition-condesation copolymers covalently bonded to silica, ceramics, titanium or zirconium oxide, used for chemical analysis WATERS INVESTMENTS LIMITED (DE) 2008-10-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160184736-A1 CHROMATOGRAPHIC COLUMNS AND SEPARATION DEVICES COMPRISING A SUPERFICIALLY POROUS MATERIAL; AND USE THEREOF FOR SUPERCRITICAL FLUID CHROMATOGRAPHY AND OTHER CHROMATOGRAPHY SPECC1L, CCL5, CCR5 LMNA 1219/4885TSHR 4745/4885THRB 4884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.