Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709088 | 0.77 | MAOA (0.41) | PNMTTAAR1HTR1ADRD2HTR7 | |
| SCHEMBL4894264 | 0.75 | TSHR (0.51) | PNMTTAAR1 | |
| SCHEMBL12760984 | 0.73 | PRCP (0.54) | DRD2 | |
| SCHEMBL10867605 | 0.72 | TAAR1 (0.35) | PNMTTAAR1HTR1ADRD2HTR7 | |
| SCHEMBL22776301 | 0.70 | PRCP (0.54) | — | |
| SCHEMBL12760983 | 0.70 | PRCP (0.54) | PNMTTAAR1 | |
| SCHEMBL8188536 | 0.70 | PRCP (0.54) | DRD2 | |
| Hydrochloric Acid SCHEMBL9789705 | 0.70 | KMT2A (0.42) | PNMTTAAR1HTR1ADRD2HTR7 | |
| SCHEMBL3312684 | 0.69 | KMT2A (0.37) | TAAR1HTR1ADRD2HTR7 | |
| SCHEMBL9531248 | 0.69 | TAAR1 (0.52) | PNMTTAAR1HTR1ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | PNMT 1313/4885TAAR1 384/4885HRH1 550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.