Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | PDE9A | O76083 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.38 |
| ▸ | GCK | P35557 | 2/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28292086 | 0.80 | LCK (0.49) | CA12CA9MAPK1PDE3BPDE3A | |
| SCHEMBL28069957 | 0.79 | GABRA1 (0.53) | CA12CA9MAPK1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL3845059 | 0.78 | TRPM8 (0.45) | PDE9APIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL14494403 | 0.73 | CA12 (0.55) | CA12CA9MAPK1MAPTPDE3B | |
| SCHEMBL4434572 | 0.72 | CA12 (0.43) | CA12CA9MAPK1PDE9AF11 | |
| SCHEMBL2017395 | 0.71 | CYP1A2 (0.46) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL23621219 | 0.69 | MAPK1 (0.49) | CA12CA9MAPK1MAPTPDE3B | |
| SCHEMBL707460 | 0.69 | F11 (0.55) | CA12CA9MAPK1PDE3BPDE3A | |
| SCHEMBL3732893 | 0.69 | MAPK1 (0.49) | CA12CA9MAPK1PDE3BPDE3A | |
| SCHEMBL29783036 | 0.69 | F11 (0.55) | CA12CA9MAPK1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111658653-B | Use of phosphodiesterase inhibitors | 药捷安康(南京)科技股份有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-113956252-A | PDE9 inhibitors and uses thereof | 药捷安康(南京)科技股份有限公司 | 2022-01-21 | — | — | CN | disclosed |
| CN-109575016-B | PDE9 inhibitors and uses thereof | 药捷安康(南京)科技股份有限公司 | 2022-01-04 | — | — | CN | disclosed |
| CN-111658653-A | Use of phosphodiesterase inhibitors | 南京药捷安康生物科技有限公司 | 2020-09-15 | — | — | CN | disclosed |