SCHEMBL284483

SCHEMBL284483

Cc1ccc(S(=O)(=O)C(=O)C(Cl)C(=O)[C@@H](N)CCCCN)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.38
GSR P00390 1/20 0.36
MMP2 P08253 4/20 0.36
MMP9 P14780 3/20 0.36
ALDH1A1 P00352 3/20 0.35
DPP8 Q6V1X1 1/20 0.35
DPP9 Q86TI2 1/20 0.35
DPP7 Q9UHL4 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
THRB P10828 1/20 0.34
LMNA P02545 2/20 0.33
NOD2 Q9HC29 2/20 0.33
CA1 P00915 1/20 0.33
SLC1A3 P43003 1/20 0.33
SLC1A2 P43004 1/20 0.33
SLC1A1 P43005 1/20 0.33
GBA1 P04062 1/20 0.33
G6PD P11413 1/20 0.33
POLB P06746 1/20 0.33
HTT P42858 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31643134 0.87 GSR (0.42) CA2GSRMMP2MMP9ALDH1A1
SCHEMBL200246 0.82 CA2 (0.41) CA2GSRMMP2MMP9ALDH1A1
SCHEMBL8630587 0.81 LARS1 (0.40) CA2MMP2ALDH1A1SMN1; SMN2LMNA
SCHEMBL3939051 0.78 GAA (0.44) CA2MMP9ALDH1A1SMN1; SMN2LMNA
SCHEMBL31643303 0.77 ALDH1A1 (0.44) CA2MMP2MMP9ALDH1A1SMN1; SMN2
SCHEMBL27752816 0.74 MMP9 (0.38) CA2MMP2MMP9ALDH1A1LMNA
Lysine SCHEMBL30145617 0.74 GSR (0.56) GSRMMP2MMP9THRBSLC1A3
Lysine SCHEMBL6683158 0.74 GSR (0.56) GSRMMP2MMP9THRBSLC1A3
Lysine SCHEMBL16553081 0.74 GSR (0.56) GSRMMP2MMP9THRBSLC1A3
SCHEMBL28583480 0.73 ALDH1A1 (0.44) CA2GSRMMP2MMP9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1708677-A2 COSMETIC COMPOSITION CONTAINING A PROTEIN AND AN ENZYME INHIBITOR E-L Management Corp. (US) 2006-10-11 EP claimed
WO-2005067691-A2 COSMETIC COMPOSITION CONTAINING A PROTEIN AND AN ENZYME INHIBITOR E-L MANAGEMENT CORPORATION (US) 2005-07-28 WO claimed
US-9795655-B2 Modified MT-SP1 proteases that inhibit complement activation CATALYST BIOSCIENCES, INC. (US) 2017-10-24 US disclosed
EP-2433642-B1 Modified proteases that inhibit complement activation CATALYST BIOSCIENCES INC (US) 2016-12-07 EP disclosed
EP-1817410-B1 HUMAN BLOOD BRAIN BARRIER MODEL INST NAT SANTE RECH MED (FR) 2015-01-07 EP disclosed
US-20140242062-A1 MODIFIED PROTEASES THAT INHIBIT COMPLEMENT ACTIVATION CATALYST BIOSCIENCES, INC. (US) 2014-08-28 US disclosed
US-20140017716-A1 PROTEOLYTIC DIGESTION KIT WITH DRIED REAGENTS SISCAPA ASSAY TECHNOLOGIES INC (US) 2014-01-16 US disclosed
EP-1940457-B1 MODIFIED PROTEASES THAT INHIBIT COMPLEMENT ACTIVATION CATALYST BIOSCIENCES INC (US) 2012-12-12 EP disclosed
US-20120244139-A1 Modified proteases that inhibit complement activation VERTEX PHARMACEUTICALS INCORPORATED 2012-09-27 US disclosed
EP-2433642-A2 Modified proteases that inhibit complement activation Catalyst Biosciences, Inc. (US) 2012-03-28 EP disclosed
EP-2428218-A1 Modified proteases that inhibit complement activation Catalyst Biosciences, Inc. (US) 2012-03-14 EP disclosed
EP-0560913-A1 BIFUNCTIONAL INHIBITORS OF THROMBIN AND PLATELET ACTIVATION BIOGEN, INC. (US) 1993-09-22 EP disclosed
US-5242810-A BIFUNCTIONAL INHIBITORS OF THROMBIN AND PLATELET ACTIVATION BIOGEN, INC. (US) 1993-09-07 US disclosed
EP-0541058-A1 Expression of a mature proteinase 2a, its partial purification and preparation of inhibitory active substrates BOEHRINGER INGELHEIM INTERNATIONAL GmbH (DE) 1993-05-12 EP disclosed
US-5196404-A Hirudin mimic, polypeptide, hirulog; bivalirudin FDA Orange book listed patent BIOGEN, INC. (US) 1993-03-23 US disclosed
WO-1993000926-A1 TREATMENT OF PERIODONTAL DISEASE WITH PROTEASE INHIBITORS CHILDREN'S MEDICAL CENTER CORPORATION (US) 1993-01-21 WO disclosed
WO-1992010575-A1 BIFUNCTIONAL INHIBITORS OF THROMBIN AND PLATELET ACTIVATION BIOGEN, INC. (US) 1992-06-25 WO disclosed
EP-0489070-A1 NOVEL INHIBITORS OF THROMBIN. BIOGEN INC (US) 1992-06-10 EP disclosed
WO-1991002750-A1 NOVEL INHIBITORS OF THROMBIN BIOGEN, INC. (US) 1991-03-07 WO disclosed
US-4906571-A Cell surface modification using a novel glycoproteinase of pasteurella haemolytica UNIVERSITY OF GUELPH (CA) 1990-03-06 US disclosed