Chloroform

Chloroform

SCHEMBL28449358

ClC(Cl)Cl.O.Oc1cc2c3cc(O)c(O)cc3c3cc(O)c(O)cc3c2cc1O

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Chloroform. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKLR known ✓ P30613 2/20 0.31
KDR known ✓ P35968 2/20 0.30
SRC P12931 5/20 0.41
PRKACA P17612 1/20 0.41
PRKACG P22612 1/20 0.41
PRKACB P22694 1/20 0.41
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
APP P05067 1/20 0.32
GALNT2 Q10471 1/20 0.31
GALNT1 Q10472 1/20 0.31
GALNT3 Q14435 1/20 0.31
GALNT10 Q86SR1 1/20 0.31
GALNT13 Q8IUC8 1/20 0.31
GALNT6 Q8NCL4 1/20 0.31
GALNT14 Q96FL9 1/20 0.31
ALOX15 P16050 1/20 0.31
ALOX12 P18054 1/20 0.31
MCL1 Q07820 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL1993869 0.86 SRC (0.50) SRCPRKACAPRKACGPRKACBHPGD
Water SCHEMBL15941074 0.86 SRC (0.50) SRCPRKACAPRKACGPRKACBHPGD
Water SCHEMBL29446320 0.86 SRC (0.50) SRCPRKACAPRKACGPRKACBHPGD
Water SCHEMBL29446319 0.86 SRC (0.50) SRCPRKACAPRKACGPRKACBHPGD
SCHEMBL29393709 0.82 SRC (0.53) SRCPRKACAPRKACGPRKACBHPGD
SCHEMBL212835 0.82 SRC (0.53) SRCPRKACAPRKACGPRKACBHPGD
SCHEMBL29384353 0.82 SRC (0.53) SRCPRKACAPRKACGPRKACBHPGD
Benzene SCHEMBL28568178 0.74 SRC (0.47) SRCPRKACAPRKACGPRKACBHPGD
SCHEMBL31154139 0.72 SRC (0.45) SRCPRKACAPRKACGPRKACBHPGD
SCHEMBL28907259 0.72 SRC (0.45) SRCPRKACAPRKACGPRKACBHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111574722-B Photoconductive metal organic framework thin film material, preparation method and application thereof 中国科学院福建物质结构研究所 2022-04-19 CN disclosed
CN-111574722-A Photoconductive metal organic framework thin film material, preparation method and application thereof 中国科学院福建物质结构研究所 2020-08-25 CN disclosed