Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 2/20 | 0.52 |
| ▸ | ALPL | P05186 | 11/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RPA1 | P27694 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29444415 | 0.83 | ALPL (0.73) | PLA2G10ALPLCA9MAPTRAB9A | |
| SCHEMBL1856249 | 0.78 | PRMT5 (0.45) | ALPLCA9MAPTRAB9APOLB | |
| SCHEMBL13162521 | 0.77 | ALK (0.62) | ALPLRAB9AALDH1A1GAANPC1 | |
| SCHEMBL2851890 | 0.77 | ALDH1A1 (0.61) | ALDH1A1TP53 | |
| SCHEMBL18726258 | 0.76 | ACR (0.57) | PLA2G10ALPLCA9MAPTRAB9A | |
| SCHEMBL4638840 | 0.76 | ALPL (0.73) | PLA2G10ALPLCA12RPA1TP53 | |
| SCHEMBL2846632 | 0.76 | ALPL (0.73) | PLA2G10ALPLMAPTALDH1A1MEN1 | |
| SCHEMBL20661049 | 0.76 | TP53 (0.51) | PLA2G10ALPLCA9MAPTRAB9A | |
| SCHEMBL2848443 | 0.76 | ALPL (0.76) | ALPLCA9MAPTRAB9APOLB | |
| SCHEMBL29444426 | 0.76 | SCN9A (0.57) | PLA2G10ALPLCA9MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130474-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | WYETH (US) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130474-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | CHRNA7, CHRNA6, CHRNA2 | PLA2G10 2656/4885ALPL 4210/4885CA9 3775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.