Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 14/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 14/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825687 | 0.79 | DAO (0.42) | CYP2C9GRIN1GRIN2BCYP11B1CYP11B2 | |
| SCHEMBL28745390 | 0.77 | RAF1 (0.36) | CYP11B1CYP11B2ADORA2A | |
| SCHEMBL29201427 | 0.76 | KMT2A (0.31) | — | |
| SCHEMBL28185742 | 0.74 | IDO1 (0.46) | — | |
| SCHEMBL2113033 | 0.72 | TLR7 (0.42) | NAMPTCYP2C9GRIN1GRIN2BHCAR2 | |
| SCHEMBL16364018 | 0.72 | CYP11B2 (0.45) | GRIN1GRIN2BHCAR2CYP11B1CYP11B2 | |
| SCHEMBL28771805 | 0.72 | TXNRD1 (0.44) | — | |
| SCHEMBL28377291 | 0.71 | AGBL2 (0.38) | ADORA2A | |
| SCHEMBL28517694 | 0.69 | APLNR (0.46) | — | |
| SCHEMBL29271395 | 0.69 | NFE2L2 (0.40) | GRIN1GRIN2BCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113508116-A | Pyrazolo [1,5-a ] pyridine derivative, and preparation method and application thereof | 察略盛医药科技(上海)有限公司 | 2021-10-15 | — | — | CN | disclosed |
| CN-111635400-A | Pyrazolo [1,5-a ] pyridine derivative, and preparation method and application thereof | 察略盛医药科技(上海)有限公司 | 2020-09-08 | — | — | CN | disclosed |