Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 3/20 | 0.39 |
| ▸ | DRD5 | P21918 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2835227 | 0.88 | SLC6A2 (0.42) | MEN1KMT2ATSHRL3MBTL1HRH4 | |
| Hydrochloric Acid SCHEMBL2840985 | 0.87 | MEN1 (0.42) | MEN1KMT2ATSHRL3MBTL1 | |
| SCHEMBL2839422 | 0.85 | MEN1 (0.39) | MEN1KMT2ATSHRL3MBTL1SIGMAR1 | |
| SCHEMBL2840148 | 0.83 | DRD1 (0.41) | TSHRDRD2DRD1DRD5DRD3 | |
| SCHEMBL2835731 | 0.82 | MEN1 (0.39) | MEN1KMT2ATSHRL3MBTL1DRD2 | |
| SCHEMBL2841105 | 0.82 | IMPDH2 (0.41) | DRD2DRD1DRD5DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL2836629 | 0.81 | MEN1 (0.41) | MEN1KMT2ATSHRL3MBTL1DRD2 | |
| SCHEMBL2841618 | 0.80 | DRD1 (0.35) | DRD2DRD1DRD5DRD3DRD4 | |
| SCHEMBL2836825 | 0.79 | SLC6A2 (0.35) | MEN1KMT2AL3MBTL1HRH4 | |
| Hydrochloric Acid SCHEMBL2844399 | 0.76 | MEN1 (0.39) | MEN1KMT2ATSHRL3MBTL1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | MEN1 3895/4885KMT2A 1371/4885TSHR 1940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.