Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2845609 | 0.85 | MEN1 (0.41) | MEN1KMT2ASIGMAR1TSHRL3MBTL1 | |
| SCHEMBL2837042 | 0.84 | SIGMAR1 (0.36) | KMT2ASIGMAR1TSHRHCRTR1HCRTR2 | |
| SCHEMBL2839725 | 0.83 | HRH3 (0.38) | MEN1KMT2ASIGMAR1TSHRL3MBTL1 | |
| SCHEMBL2840583 | 0.83 | IMPDH2 (0.38) | HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL2838274 | 0.81 | SIGMAR1 (0.34) | SIGMAR1HRH3 | |
| SCHEMBL2835227 | 0.78 | SLC6A2 (0.42) | MEN1KMT2ATSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL2844399 | 0.78 | MEN1 (0.39) | MEN1KMT2ASIGMAR1TSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL2839196 | 0.77 | MEN1 (0.36) | MEN1KMT2ASIGMAR1TSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL2840985 | 0.77 | MEN1 (0.42) | MEN1KMT2ATSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL2837889 | 0.77 | MEN1 (0.35) | MEN1KMT2ATSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | MEN1 3895/4885KMT2A 1371/4885SIGMAR1 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.