Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | CASP1 | P29466 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | CASP7 | P55210 | 3/20 | 0.67 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2845689 | 1.00 | HSD17B10 (0.67) | HSD17B10ALDH1A1CASP1HPGDCASP7 | |
| SCHEMBL2846711 | 0.95 | KDM4E (0.64) | HSD17B10ALDH1A1CASP1HPGDCASP7 | |
| SCHEMBL2846713 | 0.95 | KDM4E (0.64) | HSD17B10ALDH1A1CASP1HPGDCASP7 | |
| SCHEMBL3324053 | 0.92 | ALDH1A1 (0.75) | HSD17B10ALDH1A1CASP1HPGDCASP7 | |
| SCHEMBL2846743 | 0.90 | ALDH1A1 (0.61) | HSD17B10ALDH1A1CASP1HPGDCASP7 | |
| SCHEMBL3325607 | 0.90 | ALDH1A1 (0.69) | HSD17B10ALDH1A1CASP1HPGDCASP7 | |
| SCHEMBL2852890 | 0.90 | HSD17B10 (0.62) | HSD17B10ALDH1A1CASP1HPGDCASP7 | |
| SCHEMBL2852889 | 0.90 | HSD17B10 (0.62) | HSD17B10ALDH1A1CASP1HPGDCASP7 | |
| SCHEMBL3266248 | 0.89 | ALDH1A1 (0.73) | HSD17B10ALDH1A1CASP1HPGDCASP7 | |
| SCHEMBL3325556 | 0.88 | LMNA (0.68) | HSD17B10ALDH1A1CASP1HPGDCASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-27 | — | — | US | claimed |
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-27 | — | — | US | disclosed |
| WO-2010056907-A2 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | IAPP, PNLIP, GPR119 | HSD17B10 1951/4885ALDH1A1 2491/4885CASP1 1152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.