Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.65 |
| ▸ | MDM4 | O15151 | 4/20 | 0.65 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.65 |
| ▸ | TOP1 | P11387 | 2/20 | 0.54 |
| ▸ | TOP2A | P11388 | 1/20 | 0.54 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.54 |
| ▸ | HSD17B13 | Q7Z5P4 | 3/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11588151 | 0.84 | NPC1 (0.66) | TP53TOP1TOP2ATOP2BHSD17B13 | |
| SCHEMBL31312812 | 0.82 | TAS1R3 (0.73) | TP53MDM4MDM2TAS1R3TAS1R1 | |
| SCHEMBL25349072 | 0.81 | RAB9A (0.64) | TOP1TOP2ATOP2BHSD17B13TAS1R3 | |
| SCHEMBL333488 | 0.78 | MDM4 (1.00) | TP53MDM4MDM2MEN1KMT2A | |
| SCHEMBL6002243 | 0.76 | MDM4 (0.96) | TP53MDM4MDM2MEN1KMT2A | |
| SCHEMBL14890169 | 0.76 | CYP1A2 (0.74) | TP53MDM4MDM2ALDH1A1LMNA | |
| SCHEMBL11589239 | 0.75 | NPC1 (0.57) | TP53TOP1TOP2ATOP2BHSD17B13 | |
| SCHEMBL11589478 | 0.74 | MEN1 (0.56) | TP53TOP1TOP2ATOP2BHSD17B13 | |
| SCHEMBL11588024 | 0.73 | HSD17B13 (0.48) | TP53TOP1TOP2ATOP2BHSD17B13 | |
| SCHEMBL1520421 | 0.72 | MEN1 (0.77) | TP53MDM4MDM2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111793039-A | Preparation method of dortinode | 苏州明锐医药科技有限公司 | 2020-10-20 | — | — | CN | claimed |
| CN-111675675-A | Preparation method of dortinode | 苏州明锐医药科技有限公司 | 2020-09-18 | — | — | CN | claimed |