Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28465323 | 0.91 | LMNA (0.57) | LMNAMEN1KMT2AMAPTGAA | |
| SCHEMBL28468251 | 0.84 | MAPKAPK2 (0.52) | KMT2AMAPTTP53ABCG2KIF11 | |
| SCHEMBL29630294 | 0.79 | LMNA (0.61) | LMNAMEN1KMT2AMAPTGAA | |
| SCHEMBL28470333 | 0.79 | LMNA (0.74) | LMNAMEN1KMT2AMAPTGAA | |
| SCHEMBL9401163 | 0.79 | LMNA (0.70) | LMNAMEN1KMT2AMAPTGAA | |
| SCHEMBL8372051 | 0.76 | LMNA (0.69) | LMNAMEN1KMT2AMAPTGAA | |
| SCHEMBL28468254 | 0.75 | KIF11 (0.52) | LMNAMAPTTP53ABCG2KIF11 | |
| SCHEMBL12831402 | 0.75 | HDAC1 (0.61) | LMNAMEN1KMT2AMAPTGAA | |
| SCHEMBL17520528 | 0.74 | LMNA (0.73) | LMNAMEN1KMT2AMAPTGAA | |
| SCHEMBL28470335 | 0.73 | ABCB1 (0.43) | GAAACHEPOLBABCG2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111675725-A | Tetrahydro-beta-carbaline dimer and preparation method and application thereof | 中国药科大学 | 2020-09-18 | — | — | CN | disclosed |