Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.57 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29142619 | 0.92 | ZDHHC20 (0.53) | ZDHHC20ZDHHC2HTTDNM1KMT2A | |
| Hydrochloric Acid SCHEMBL336794 | 0.86 | ZDHHC20 (0.46) | ZDHHC20ZDHHC2KMT2ATHRATHRB | |
| Hydrochloric Acid SCHEMBL11232338 | 0.86 | ZDHHC20 (0.70) | ZDHHC20ZDHHC2HTTDNM1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL29634898 | 0.86 | ZDHHC20 (0.65) | ZDHHC20ZDHHC2HTTDNM1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL2489185 | 0.86 | ZDHHC20 (0.70) | ZDHHC20ZDHHC2HTTDNM1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL3046560 | 0.86 | ZDHHC20 (0.70) | ZDHHC20ZDHHC2HTTDNM1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL28572838 | 0.86 | ZDHHC20 (0.70) | ZDHHC20ZDHHC2HTTDNM1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL10416603 | 0.85 | ZDHHC20 (0.59) | ZDHHC20ZDHHC2DNM1THRATHRB | |
| SCHEMBL4126549 | 0.84 | ZDHHC20 (0.47) | ZDHHC20ZDHHC2DNM1KMT2ATHRA | |
| SCHEMBL16799012 | 0.84 | ZDHHC20 (0.72) | ZDHHC20ZDHHC2HTTDNM1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111836667-B | Improvements in or relating to organic compounds | 奇华顿股份有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-112739454-B | Improvements in or relating to organic compounds | 奇华顿股份有限公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-111836667-A | Improvements in or relating to organic compounds | 奇华顿股份有限公司 | 2020-10-27 | — | — | CN | disclosed |