SCHEMBL28476797

SCHEMBL28476797

C=CC(=O)Oc1ccc(Cl)c(O)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 3/20 0.44
CYP3A4 P08684 2/20 0.41
HSD17B10 Q99714 2/20 0.41
ALDH1A1 P00352 1/20 0.41
TSHR P16473 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
MEN1 O00255 1/20 0.40
ESR1 P03372 1/20 0.40
PKM P14618 1/20 0.40
KMT2A Q03164 1/20 0.40
ESR2 Q92731 1/20 0.40
HSP90AA1 P07900 1/20 0.37
KDM4E B2RXH2 2/20 0.36
NR1H4 Q96RI1 3/20 0.35
KDM4A O75164 1/20 0.35
KDM5C P41229 1/20 0.35
KDM4D Q6B0I6 1/20 0.35
KDM4C Q9H3R0 1/20 0.35
CHEK2 O96017 1/20 0.34
ABCG2 Q9UNQ0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11347302 0.85 THRB (0.46) THRBALDH1A1TSHRHSP90AA1KDM4E
Hydrochloric Acid SCHEMBL27792633 0.84 THRB (0.45) THRBALDH1A1TSHRHSP90AA1KDM4E
SCHEMBL21170004 0.83 THRB (0.47) THRBCYP3A4HSD17B10ALDH1A1TDP1
SCHEMBL11225929 0.83 THRB (0.47) THRBCYP3A4HSD17B10ALDH1A1TDP1
SCHEMBL17355739 0.81 MCL1 (0.53) THRBALDH1A1TDP1MEN1PKM
SCHEMBL11253852 0.80 THRB (0.45) THRBCYP3A4HSD17B10ALDH1A1TSHR
SCHEMBL8512513 0.79 NPC1 (0.58) THRBCYP3A4HSD17B10ALDH1A1TSHR
SCHEMBL31169459 0.79 NPC1 (0.58) THRBCYP3A4HSD17B10ALDH1A1TSHR
SCHEMBL10694878 0.79 THRB (0.47) THRBCYP3A4ALDH1A1TSHRTDP1
SCHEMBL28475721 0.79 THRB (0.44) THRBCYP3A4MEN1KMT2ACHEK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108101786-B Method for synthesizing phenoxyalkenyl ether compound by catalyzing palladium salt 西南大学 2020-09-22 CN disclosed