Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 8/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28481286 | 0.76 | RIPK1 (0.54) | MEN1KMT2AALDH1A1MAPTRIPK1 | |
| SCHEMBL8187984 | 0.72 | PTGS1 (0.76) | PTGS1PTGS2MEN1KMT2AALDH1A1 | |
| SCHEMBL27282266 | 0.72 | MEN1 (0.57) | MEN1KMT2ARIPK1MAOAMAOB | |
| SCHEMBL13909028 | 0.71 | PTGS1 (0.55) | PTGS1PTGS2PDE5AMEN1KMT2A | |
| SCHEMBL4020011 | 0.69 | PTGS2 (0.76) | PTGS1PTGS2ALDH1A1MAPT | |
| SCHEMBL5693406 | 0.69 | PTGS2 (0.76) | PTGS1PTGS2PDE5AMEN1KMT2A | |
| SCHEMBL28763728 | 0.68 | PTGS1 (0.55) | PTGS1PTGS2PDE5AALDH1A1MAPT | |
| SCHEMBL8199116 | 0.68 | PTGS2 (0.76) | PTGS1PTGS2MEN1KMT2AMAPT | |
| SCHEMBL5713114 | 0.67 | PRKCZ (0.43) | PTGS1PTGS2PDE5AMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL23801079 | 0.67 | RIPK1 (0.52) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112370452-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-107624111-B | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-11-03 | — | — | CN | disclosed |