Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TERT | O14746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28478706 | 0.76 | PTGS1 (0.43) | RIPK1MAPTALDH1A1MAOAMAOB | |
| SCHEMBL17012695 | 0.75 | MAOB (0.64) | RIPK1MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8103392 | 0.74 | MAPT (0.68) | RIPK1MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9370534 | 0.72 | LMNA (0.75) | RIPK1GAALMNAMAOBKIF11 | |
| SCHEMBL18248229 | 0.70 | TERT (0.72) | RIPK1GAALMNAMAOAMAOB | |
| SCHEMBL18255056 | 0.70 | RIPK1 (1.00) | RIPK1GAALMNATERTKIF11 | |
| SCHEMBL20138345 | 0.69 | RIPK1 (0.51) | RIPK1ALDH1A1 | |
| SCHEMBL28689541 | 0.69 | RIPK1 (0.51) | RIPK1ALDH1A1 | |
| SCHEMBL20161261 | 0.69 | RIPK1 (0.51) | RIPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28469788 | 0.68 | RIPK1 (0.50) | RIPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112370452-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-107624111-B | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-11-03 | — | — | CN | disclosed |