Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.77 |
| ▸ | CA1 | P00915 | 6/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL15821222 | 1.00 | CA2 (0.77) | CA2CA1CYP3A4TSHRNFKB1 | |
| SCHEMBL30685115 | 0.96 | CA2 (0.84) | CA2CA1CYP3A4TSHRNFKB1 | |
| Lithium Ion SCHEMBL22772374 | 0.96 | CA2 (0.77) | CA2CA1CYP3A4TSHRNFKB1 | |
| SCHEMBL28366820 | 0.96 | CA2 (0.77) | CA2CA1CYP3A4TSHRNFKB1 | |
| SCHEMBL10944798 | 0.96 | CA2 (0.77) | CA2CA1CYP3A4TSHRNFKB1 | |
| SCHEMBL5057190 | 0.96 | CA2 (0.77) | CA2CA1CYP3A4TSHRNFKB1 | |
| SCHEMBL3839235 | 0.96 | CA2 (0.84) | CA2CA1CYP3A4TSHRNFKB1 | |
| SCHEMBL22772366 | 0.96 | CA2 (0.77) | CA2CA1CYP3A4TSHRNFKB1 | |
| SCHEMBL22772375 | 0.96 | CA2 (0.77) | CA2CA1CYP3A4TSHRNFKB1 | |
| SCHEMBL28957154 | 0.96 | CA2 (0.77) | CA2CA1CYP3A4TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112041310-A | Process for preparing N-acylated amino acid esters comprising an acid-labile ketone protecting group | 拜耳公司 | 2020-12-04 | — | — | CN | disclosed |