Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 9/20 | 0.59 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.57 |
| ▸ | TTR | P02766 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30615706 | 1.00 | FTO (0.59) | FTOPBRM1TTRMEN1ADORA3 | |
| SCHEMBL4249088 | 0.82 | PBRM1 (0.75) | FTOPBRM1TTRMEN1ADORA3 | |
| SCHEMBL30575470 | 0.82 | PBRM1 (0.75) | FTOPBRM1TTRMEN1ADORA3 | |
| SCHEMBL10144160 | 0.82 | PTGS2 (0.59) | FTOTTRMEN1ADORA3PTGS2 | |
| SCHEMBL28297347 | 0.80 | PBRM1 (0.73) | FTOPBRM1TTRMEN1ADORA3 | |
| SCHEMBL28487702 | 0.80 | METTL3 (0.58) | FTOKMT2ALMNAMAPTHPGD | |
| SCHEMBL355549 | 0.78 | FABP4 (0.80) | PBRM1TTRMEN1ADORA3PTGS2 | |
| SCHEMBL30320327 | 0.78 | FABP4 (0.80) | PBRM1TTRMEN1ADORA3PTGS2 | |
| SCHEMBL15286534 | 0.78 | KDM4C (0.57) | FABP4AURKAKDM4DKDM4C | |
| SCHEMBL693586 | 0.78 | PBRM1 (0.56) | FTOPBRM1TTRMEN1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868037-B | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2023-10-13 | — | — | CN | disclosed |
| CN-111868037-A | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2020-10-30 | — | — | CN | disclosed |