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Escin Ia

Escin Ia

SCHEMBL284871

C/C=C(/C)C(=O)O[C@H]1[C@H](OC(C)=O)[C@@]2(CO)C(CC1(C)C)C1=CCC3[C@@]4(C)CCC(O[C@@H]5O[C@H](C(=O)O)[C@@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@](C)(CO)C4CC[C@@]3(C)[C@]1(C)C[C@H]2O.C/C=C(\C)C(=O)O[C@H]1[C@H](OC(C)=O)[C@@]2(CO)C(CC1(C)C)C1=CCC3[C@@]4(C)CCC(O[C@@H]5O[C@H](C(=O)O)[C@@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@](C)(CO)C4CC[C@@]3(C)[C@]1(C)C[C@H]2O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ CXCR5 P32302 1/20 1.00
▸ APLNR P35414 1/20 1.00
▸ CCR6 P51684 1/20 1.00
▸ TOP1 P11387 13/20 0.90
▸ SLCO1B3 Q9NPD5 1/20 0.81
▸ SLCO1B1 Q9Y6L6 1/20 0.81
▸ CRHBP P24387 2/20 0.76
▸ CRHR2 Q13324 2/20 0.76
▸ F3 P13726 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Escin Ia SCHEMBL13007226 1.00 CXCR5 (1.00) CXCR5APLNRCCR6TOP1SLCO1B3
Escin Ia SCHEMBL13990760 1.00 CXCR5 (1.00) CXCR5APLNRCCR6TOP1SLCO1B3
Escin Ia SCHEMBL13007215 1.00 CXCR5 (1.00) CXCR5APLNRCCR6TOP1SLCO1B3
Escin Ia SCHEMBL167245 1.00 CXCR5 (1.00) CXCR5APLNRCCR6TOP1SLCO1B3
Escin Ia SCHEMBL18947797 1.00 CXCR5 (1.00) CXCR5APLNRCCR6TOP1SLCO1B3
Escin Ia SCHEMBL19361964 1.00 CXCR5 (1.00) CXCR5APLNRCCR6TOP1SLCO1B3
Escin Ib SCHEMBL23883543 1.00 CXCR5 (1.00) CXCR5APLNRCCR6TOP1SLCO1B3
Escin Ia SCHEMBL6246175 1.00 CXCR5 (1.00) CXCR5APLNRCCR6TOP1SLCO1B3
Escin Ib SCHEMBL15531983 1.00 CXCR5 (1.00) CXCR5APLNRCCR6TOP1SLCO1B3
Escin Ia SCHEMBL29434526 1.00 CXCR5 (1.00) CXCR5APLNRCCR6TOP1SLCO1B3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101239082-A Preparation of buckeye total saponins and its anti-obesity function UNIV JILIN AGRICULTURAL (CN) 2008-08-13 — — CN claimed
US-20250381110-A1 SKIN CARE COMPOSITION AND METHOD OF USING THE SAME PROCTER & GAMBLE (US) 2025-12-18 — — US disclosed
CN-119896224-A Application of aescin in preparation of insect antifeedant for fruit fly 西南大学 2025-04-29 — — CN disclosed
WO-2025028262-A1 OPTICAL LAYERED BODY 住友化学株式会社 2025-02-06 — — WO disclosed
WO-2025028263-A1 OPTICAL LAMINATE 住友化学株式会社 2025-02-06 — — WO disclosed
CN-119350425-A Template molecule, molecular imprinting polymer and application thereof in separation of saponins compounds 广州伽能生物科技有限公司 2025-01-24 — — CN disclosed
CN-119318661-A Pharmaceutical composition for treating TDP-43 protein diseases, and preparation method and application thereof 中国科学院生物物理研究所 2025-01-17 — — CN disclosed
WO-2024042818-A1 LAMINATE AND ORGANIC EL DISPLAY DEVICE 住友化学株式会社 2024-02-29 — — WO disclosed
WO-2024024889-A1 OPTICAL LAYERED BODY 住友化学株式会社 2024-02-01 — — WO disclosed
WO-2024024890-A1 OPTICAL LAMINATE 住友化学株式会社 2024-02-01 — — WO disclosed
CN-108969444-A One kind removing black eye, crease-resistant Firm anti-age corrective eye treatment cream and preparation method thereof 陈洁珍 2018-12-11 — — CN disclosed
US-20170367973-A1 COMPOSITIONS COMPRISING MACROMOLECULAR ASSEMBLIES OF LIPID AND SURFACTANT MALVERN COSMECEUTICS LIMITED (GB) 2017-12-28 — — US disclosed
CN-105612091-A Vehicle motion control device HITACHI AUTOMOTIVE SYSTEMS LTD 2016-05-25 — — CN disclosed
US-20160022569-A1 COMPOSITIONS COMPRISING MACROMOLECULAR ASSEMBLIES OF LIPID AND SURFACTANT MALVERN COSMECEUTICS LIMITED (GB) 2016-01-28 — — US disclosed
CN-101583339-B Compositions comprising macromolecular assemblies of lipid and surfactant MALVERN COSMECEUTICS LTD 2013-10-23 — — CN disclosed
EP-2428200-A2 Novel compositions Malvern Cosmeceutics Limited (GB) 2012-03-14 — — EP disclosed
US-20100062067-A1 COMPOSITIONS COMPRISING MACROMOLECULAR ASSEMBLIES OF LIPID AND SURFACTANT MALVERN COSMECEUTICS LIMITED (GB) 2010-03-11 — — US disclosed
CN-101583339-A Compositions comprising macromolecular assemblies of lipid and surfactant MALVERN COSMECEUTICS LTD (GB) 2009-11-18 — — CN disclosed
EP-2099410-A2 COMPOSITIONS COMPRISING MACROMOLECULAR ASSEMBLIES OF LIPID AND SURFACTANT Malvern Cosmeceutics Limited (GB) 2009-09-16 — — EP disclosed
WO-2008065451-A2 COMPOSITIONS COMPRISING MACROMOLECULAR ASSEMBLIES OF LIPID AND SURFACTANT MALVERN COSMECEUTICS LIMITED (GB) 2008-06-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170367973-A1 COMPOSITIONS COMPRISING MACROMOLECULAR ASSEMBLIES OF LIPID AND SURFACTANT APOB, CLTB, ABCB4 CXCR5 4508/4885APLNR 1159/4885CCR6 3817/4885
US-20160022569-A1 COMPOSITIONS COMPRISING MACROMOLECULAR ASSEMBLIES OF LIPID AND SURFACTANT APOB, CLTB, ABCB4 CXCR5 4508/4885APLNR 1159/4885CCR6 3817/4885
US-20250381110-A1 SKIN CARE COMPOSITION AND METHOD OF USING THE SAME SQSTM1, BECN1, CUTA CXCR5 4311/4885APLNR 2879/4885CCR6 4492/4885
US-20100062067-A1 COMPOSITIONS COMPRISING MACROMOLECULAR ASSEMBLIES OF LIPID AND SURFACTANT CLTB, APOB, ABCB4 CXCR5 4743/4885APLNR 1302/4885CCR6 3962/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.