Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.64 |
| ▸ | TYMS | P04818 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | DHFR | P00374 | 3/20 | 0.61 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.58 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.58 |
| ▸ | ATIC | P31939 | 4/20 | 0.58 |
| ▸ | GART | P22102 | 7/20 | 0.57 |
| ▸ | FPGS | Q05932 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2166341 | 0.81 | MTHFD1 (0.63) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL17097094 | 0.81 | MTHFD1 (0.63) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL12136386 | 0.79 | SOST (0.61) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL27589172 | 0.79 | SOST (0.61) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL8282 | 0.79 | SOST (0.61) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL8281 | 0.79 | SOST (0.61) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL1537882 | 0.78 | SOST (0.65) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL9413322 | 0.78 | SOST (0.65) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Tetrahydrofolate SCHEMBL2691812 | 0.78 | SOST (1.00) | SOSTDHFRMTHFD1MTHFD2ATIC | |
| Tetrahydrofolate SCHEMBL8030 | 0.78 | SOST (1.00) | SOSTDHFRMTHFD1MTHFD2ATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111989138-A | Humanized anti-Prostate Specific Membrane Antigen (PSMA) antibody drug conjugates | AMBRX公司 | 2020-11-24 | — | — | CN | disclosed |