Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 11/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856272 | 0.86 | MALT1 (0.53) | MALT1KDM4EALDH1A1METAXL | |
| SCHEMBL2855950 | 0.82 | POLB (0.41) | MALT1KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL21604788 | 0.81 | MALT1 (0.71) | MALT1 | |
| SCHEMBL2855512 | 0.81 | MALT1 (0.55) | MALT1KDM4EALDH1A1METAXL | |
| SCHEMBL2852336 | 0.80 | SMN1; SMN2 (0.74) | KDM4EALDH1A1NPC1RAB9APOLB | |
| SCHEMBL2858127 | 0.80 | ALDH1A1 (0.74) | KDM4EALDH1A1NPC1RAB9AMET | |
| SCHEMBL30147306 | 0.79 | MAPT (0.57) | KDM4EALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL2849153 | 0.78 | MAPT (0.56) | MALT1KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL2854476 | 0.78 | MALT1 (0.56) | MALT1KDM4ESMN1; SMN2 | |
| SCHEMBL2850226 | 0.77 | MALT1 (0.56) | MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |