SCHEMBL2849643

SCHEMBL2849643

CC[C@@](CCCCBr)(C(=O)O)C(=O)OC

nearest known ligand 0.33

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 2/20 0.33
PTPRB P23467 2/20 0.32
THRB P10828 1/20 0.32
PKM P14618 1/20 0.32
CYP4F2 P78329 1/20 0.32
CYP4A11 Q02928 1/20 0.32
ARG1 P05089 1/20 0.31
ARG2 P78540 1/20 0.31
HTT P42858 1/20 0.31
PTPRC P08575 1/20 0.31
PTPN2 P17706 1/20 0.31
PTPRG P23470 1/20 0.31
ACP1 P24666 1/20 0.31
TSHR P16473 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2849564 0.87 ARG1 (0.35) THRBARG1ARG2
SCHEMBL28935351 0.85 MEN1 (0.40) PTPN1TSHR
SCHEMBL28697226 0.84 MEN1 (0.42) PTPN1TSHR
SCHEMBL27692685 0.83 KMT2A (0.37) PTPN1PTPRBPTPRCPTPN2PTPRG
SCHEMBL2851915 0.83 KMT2A (0.37) PTPN1PTPRBPTPRCPTPN2PTPRG
SCHEMBL15233819 0.81 TSHR (0.37) PTPN1PTPRBPTPRCPTPN2PTPRG
SCHEMBL221073 0.78 PTPN1 (0.40) PTPN1PTPRBTHRBPTPN2TSHR
SCHEMBL10444862 0.77 KMT2A (0.38) PTPN1PTPRBPTPRCPTPN2PTPRG
SCHEMBL11713600 0.76
SCHEMBL10575269 0.76 MEN1 (0.31) THRBARG1ARG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100160670-A1 NOVEL PROCESS FOR THE PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM HEXANOIC ACID ESTERS AND INTERMEDIATES USED IN THE SYNTHESIS OF CHIRAL-2-(BROMOMETHYL)-2-ETHYLHEXANOIC ACID AVENTIS PHARMA S.A. (FR) 2010-06-24 US disclosed
US-20090163737-A1 NOVEL PROCESS FOR THE PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM HEXANOIC ACID ESTERS AND INTERMEDIATES USED IN THE SYNTHESIS OF CHIRAL 2-(BROMOMETHYL)-2-ETHYLHEXANOIC ACID AVENTIS PHARMA S.A. (FR) 2009-06-25 US disclosed
US-20080108847-A1 NOVEL PROCESS FOR THE PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM HEXANOIC ACID ESTERS AND INTERMEDIATES USED IN THE SYNTHESIS OF CHIRAL2-(BROMOMETHYL)-2-ETHYLHEXANOIC ACID AVENTIS PHARMA S.A. (FR) 2008-05-08 US disclosed
US-20040147774-A1 Novel chiral compounds derived from hexanoic acid esters, preparation process and intermediates, use in the synthesis of chiral 2-(bromomethyl)-2-ethylhexanoic acid AVENTIS PHARMA S.A. (FR) 2004-07-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080108847-A1 NOVEL PROCESS FOR THE PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM HEXANOIC ACID ESTERS AND INTERMEDIATES USED IN THE SYNTHESIS OF CHIRAL2-(BROMOMETHYL)-2-ETHYLHEXANOIC ACID HCAR2, HCAR3, HCAR1 PTPN1 4675/4885PTPRB 4532/4885THRB 445/4885
US-20090163737-A1 NOVEL PROCESS FOR THE PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM HEXANOIC ACID ESTERS AND INTERMEDIATES USED IN THE SYNTHESIS OF CHIRAL 2-(BROMOMETHYL)-2-ETHYLHEXANOIC ACID HCAR3, HCAR2, HCAR1 PTPN1 4638/4885PTPRB 4457/4885THRB 341/4885
US-20040147774-A1 Novel chiral compounds derived from hexanoic acid esters, preparation process and intermediates, use in the synthesis of chiral 2-(bromomethyl)-2-ethylhexanoic acid HCAR2, FFAR2, HCAR3 PTPN1 4227/4885PTPRB 4505/4885THRB 507/4885
US-20100160670-A1 NOVEL PROCESS FOR THE PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM HEXANOIC ACID ESTERS AND INTERMEDIATES USED IN THE SYNTHESIS OF CHIRAL-2-(BROMOMETHYL)-2-ETHYLHEXANOIC ACID HCAR2, HCAR3, HCAR1 PTPN1 4580/4885PTPRB 4314/4885THRB 356/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.