Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MDM4 | O15151 | 2/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28514431 | 0.89 | TP53 (0.52) | CYP11B1CYP11B2TP53MDM4MDM2 | |
| SCHEMBL28503167 | 0.89 | TP53 (0.56) | ALDH1A1CYP11B1CYP11B2TP53MDM4 | |
| SCHEMBL28505102 | 0.87 | CYP11B1 (0.49) | ALDH1A1CYP11B1CYP11B2TP53MDM4 | |
| SCHEMBL28506698 | 0.87 | MDM4 (0.48) | ALDH1A1CYP11B1CYP11B2TP53MDM4 | |
| SCHEMBL28505021 | 0.86 | HTR1A (0.53) | TP53MDM4MDM2HTR1ADRD2 | |
| SCHEMBL28492793 | 0.84 | MDM2 (0.62) | ALDH1A1CYP11B1CYP11B2TP53MDM4 | |
| SCHEMBL28501197 | 0.82 | MDM2 (0.52) | ALDH1A1CYP11B1CYP11B2TP53MDM4 | |
| SCHEMBL28504165 | 0.82 | MDM2 (0.52) | ALDH1A1CYP11B1CYP11B2TP53MDM4 | |
| SCHEMBL28508709 | 0.81 | HTR1A (0.52) | ALDH1A1CYP11B1CYP11B2TP53MDM4 | |
| SCHEMBL28501215 | 0.81 | KDM4E (0.50) | CYP11B1TP53MDM4MDM2SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112174937-B | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-112174937-A | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2021-01-05 | — | — | CN | disclosed |