Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MDM4 | O15151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28506801 | 0.88 | TP53 (0.48) | CYP11B1CYP11B2ALDH1A1MDM4TP53 | |
| SCHEMBL28508740 | 0.87 | TP53 (0.52) | CYP11B1CYP11B2ALDH1A1MDM4TP53 | |
| SCHEMBL28508702 | 0.87 | MDM4 (0.44) | CYP11B1CYP11B2ALDH1A1MDM4TP53 | |
| SCHEMBL28497040 | 0.87 | ALDH1A1 (0.49) | CYP11B1CYP11B2ALDH1A1MDM4TP53 | |
| SCHEMBL28496318 | 0.86 | HTR1A (0.53) | MDM4TP53MDM2HTR1ADRD2 | |
| SCHEMBL28904632 | 0.82 | MDM2 (0.60) | CYP11B1CYP11B2ALDH1A1MDM4TP53 | |
| SCHEMBL28499278 | 0.81 | KDM4E (0.50) | CYP11B1MDM4TP53MDM2HTR7 | |
| SCHEMBL28503127 | 0.81 | MDM4 (0.48) | CYP11B1CYP11B2ALDH1A1MDM4TP53 | |
| SCHEMBL28507696 | 0.81 | SMN1; SMN2 (0.48) | CYP11B1CYP11B2ALDH1A1MDM4TP53 | |
| SCHEMBL28495988 | 0.80 | HTR1A (0.51) | CYP11B2ALDH1A1MDM4TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112174937-B | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-112174937-A | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2021-01-05 | — | — | CN | disclosed |