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Sugi Predict / Compounds / Tyrosine

Tyrosine

Tyrosine

SCHEMBL28498362

CC(C)C[C@H](N)C(=O)O.CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCC(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ F2 P00734 4/20 0.38
▸ REN P00797 2/20 0.35
▸ NPY1R P25929 1/20 0.34
▸ NPY2R P49146 1/20 0.34
▸ CRHR1 P34998 1/20 0.34
▸ CRHR2 Q13324 1/20 0.34
▸ CALCR P30988 5/20 0.34
▸ GLP1R P43220 6/20 0.33
▸ KLK7 P49862 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL28490008 0.93 REN (0.39) RENNPY1R
Tyrosine SCHEMBL6253686 0.92 REN (0.38) RENNPY1R
Tyrosine SCHEMBL9538046 0.89 CRHR1 (0.40) F2NPY1RNPY2RCRHR1CRHR2
Tyrosine SCHEMBL8185595 0.89 F2 (0.35) F2NPY1RNPY2RCRHR1CRHR2
Tyrosine SCHEMBL4948067 0.86 SLC7A5 (0.35) —
Tyrosine SCHEMBL6157198 0.86 SLC7A5 (0.35) —
Phenylalanine SCHEMBL1239600 0.86 GHSR (0.35) REN
Tyrosine SCHEMBL294953 0.86 REN (0.38) RENNPY1R
Tyrosine SCHEMBL6511987 0.86 SLC7A5 (0.36) F2NPY1RNPY2R
Tyrosine SCHEMBL6387322 0.86 REN (0.36) REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112010947-B Cyclohexadecapeptide with angiotensin converting enzyme inhibitory activity and preparation method and application thereof 中新国际联合研究院 2022-05-24 — — CN claimed
CN-112010947-A Cyclohexadecapeptide with angiotensin converting enzyme inhibitory activity and preparation method and application thereof 中新国际联合研究院 2020-12-01 — — CN claimed
CN-112010947-B Cyclohexadecapeptide with angiotensin converting enzyme inhibitory activity and preparation method and application thereof 中新国际联合研究院 2022-05-24 — — CN disclosed
CN-112010947-A Cyclohexadecapeptide with angiotensin converting enzyme inhibitory activity and preparation method and application thereof 中新国际联合研究院 2020-12-01 — — CN disclosed