SCHEMBL28499366

SCHEMBL28499366

COC(=O)c1cc(-c2ccccc2)cc(N(Cc2ccccc2)Cc2ccccc2)c1OC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 3/20 0.43
CNR2 P34972 3/20 0.43
MAPK1 P28482 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
ALDH1A1 P00352 6/20 0.42
KDM4E B2RXH2 4/20 0.42
HPGD P15428 3/20 0.42
NPSR1 Q6W5P4 1/20 0.42
NR3C1 P04150 2/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
GAA P10253 1/20 0.41
MAPT P10636 1/20 0.41
LMNA P02545 2/20 0.41
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39
IKBKB O14920 1/20 0.39
ACLY P53396 1/20 0.39
MTNR1A P48039 1/20 0.39
MTNR1B P49286 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1612858 0.77 KMT2A (0.53) L3MBTL1ALDH1A1KDM4ENR3C1MEN1
SCHEMBL28500196 0.76 HSD17B2 (0.37) MAPK1L3MBTL1ALDH1A1KDM4ENPSR1
SCHEMBL22014036 0.75 NR3C1 (0.48) ALDH1A1KDM4EHPGDNR3C1MEN1
SCHEMBL30910355 0.73 PLA2G2A (0.49) ALDH1A1KDM4EHPGDNR3C1MEN1
SCHEMBL28316742 0.72 LMNA (0.47) ALDH1A1KDM4EHPGDNR3C1MEN1
SCHEMBL5126226 0.71 RXRA (0.42) MAPK1L3MBTL1ALDH1A1KDM4EMEN1
SCHEMBL12950801 0.70 CRHBP (0.51) CNR2ALDH1A1KDM4EHPGDNR3C1
SCHEMBL30394561 0.70 SLC16A3 (0.52) L3MBTL1HPGDNPSR1MAPTLMNA
SCHEMBL26105961 0.70 SLC16A3 (0.52) L3MBTL1HPGDNPSR1MAPTLMNA
SCHEMBL28726425 0.70 TSHR (0.53) ALDH1A1KDM4EHPGDMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112119077-A Kinase inhibitors 曼彻斯特大学 2020-12-22 CN disclosed