SCHEMBL2849972

SCHEMBL2849972

O=C(Nc1cnn(-c2ccc(Cl)cc2)c1C(F)(F)F)N(CC1=COCO1)Cc1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.40
NPSR1 Q6W5P4 4/20 0.40
MAPK1 P28482 2/20 0.40
HSP90AA1 P07900 1/20 0.40
GAA P10253 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
ABCB1 P08183 1/20 0.37
KDM4E B2RXH2 1/20 0.37
MAPT P10636 4/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
POLB P06746 1/20 0.35
CCR1 P32246 3/20 0.35
PTPN1 P18031 1/20 0.34
GPR6 P46095 1/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
LMNA P02545 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2854455 0.80 KMT2A (0.50) ALDH1A1NPSR1MAPK1GAAABCB1
SCHEMBL2858117 0.76 MAPT (0.41) ALDH1A1NPSR1MAPK1KDM4EMAPT
SCHEMBL2855318 0.76 ROCK1 (0.43) ALDH1A1NPSR1MAPK1HSP90AA1GAA
SCHEMBL2856094 0.74 MAPT (0.42) ALDH1A1NPSR1KDM4EMAPTNPC1
SCHEMBL2853232 0.73 CCR1 (0.48) ALDH1A1NPSR1MAPK1KDM4EMAPT
SCHEMBL2858009 0.72 SMN1; SMN2 (0.43) ALDH1A1MAPK1GAAKDM4EMAPT
SCHEMBL2855846 0.72 CNR1 (0.55) ALDH1A1NPSR1KDM4EMAPTNPC1
SCHEMBL2859025 0.71 NAMPT (0.44) ALDH1A1NPSR1MAPK1ABCB1MAPT
SCHEMBL2856146 0.71 CNR1 (0.53) ALDH1A1NPSR1MAPK1ABCB1KDM4E
SCHEMBL2854032 0.71 MAPT (0.43) ALDH1A1NPSR1GAAKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1451160-B1 PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN ICAGEN INC (US) 2010-01-13 EP disclosed