Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854455 | 0.91 | KMT2A (0.50) | ALDH1A1MEN1MAPK1KMT2ARECQL | |
| SCHEMBL2859025 | 0.84 | NAMPT (0.44) | ALDH1A1LMNAMEN1MAPK1KMT2A | |
| SCHEMBL2855318 | 0.77 | ROCK1 (0.43) | ALDH1A1MAPK1GAAMAPTROCK1 | |
| SCHEMBL2850439 | 0.77 | KMT2A (0.53) | MEN1MAPK1KMT2A | |
| SCHEMBL2853095 | 0.77 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1MEN1MAPK1KMT2A | |
| SCHEMBL2856094 | 0.76 | MAPT (0.42) | SMN1; SMN2ALDH1A1POLBMAPTKDM4E | |
| SCHEMBL2858117 | 0.75 | MAPT (0.41) | SMN1; SMN2ALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL2854032 | 0.73 | MAPT (0.43) | SMN1; SMN2ALDH1A1POLBGAAMAPT | |
| SCHEMBL2856366 | 0.72 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1LMNAMAPK1POLB | |
| SCHEMBL2849972 | 0.72 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1LMNAMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |