Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NNMT | P40261 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.37 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22658302 | 0.81 | ROCK1 (0.42) | ABL1ROCK1KDM4EMAPTGAA | |
| SCHEMBL29433388 | 0.81 | ROCK1 (0.42) | ABL1ROCK1KDM4EMAPTGAA | |
| SCHEMBL14267861 | 0.76 | APP (0.53) | HCAR3NNMTAPPMAPTGAA | |
| SCHEMBL12147787 | 0.75 | RXRA (0.41) | ABL1KDM4EMAPTMBOAT4GRM5 | |
| Hydrochloric Acid SCHEMBL29005140 | 0.73 | HCAR3 (0.40) | HCAR3ABL1NNMTAPPHCRTR1 | |
| SCHEMBL24665317 | 0.72 | CHRNB2 (0.39) | ROCK1ALOX15GFERADAM17LMNA | |
| SCHEMBL30005327 | 0.72 | CHRNB2 (0.39) | ROCK1ALOX15GFERADAM17LMNA | |
| Hydrochloric Acid SCHEMBL7001795 | 0.72 | HCAR3 (0.42) | HCAR3NNMTAPPMAPT | |
| SCHEMBL27978103 | 0.72 | KDM4E (0.60) | NNMTKDM4EMAPTHCRTR1NPC1 | |
| SCHEMBL12248266 | 0.72 | KDM4E (0.38) | ROCK1KDM4EMAPTMBOAT4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112204006-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-11-28 | — | — | CN | disclosed |
| CN-112204006-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2021-01-08 | — | — | CN | disclosed |
| CN-112166113-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2021-01-01 | — | — | CN | disclosed |