Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24665317 | 1.00 | CHRNB2 (0.39) | CHRNB2CHRNA4DRD1MEN1ALDH1A1 | |
| SCHEMBL31043196 | 0.81 | SYK (0.43) | CHRNB2CHRNA4KMT2A | |
| SCHEMBL4741323 | 0.81 | SYK (0.43) | CHRNB2CHRNA4KMT2A | |
| SCHEMBL29433330 | 0.77 | CHRNA3 (0.41) | CHRNB2CHRNA4LMNAKMT2A | |
| SCHEMBL27978361 | 0.77 | ALOX15 (0.39) | DRD1MEN1ALDH1A1LMNAHSP90AA1 | |
| SCHEMBL19837604 | 0.77 | DRD1 (0.36) | DRD1MEN1ALDH1A1LMNAHSP90AA1 | |
| SCHEMBL1002255 | 0.77 | MPO (0.43) | DRD1MEN1ALDH1A1LMNAHSP90AA1 | |
| SCHEMBL12147787 | 0.77 | RXRA (0.41) | CHRNB2CHRNA4DRD1KMT2A | |
| SCHEMBL30187182 | 0.77 | ALOX15 (0.39) | CHRNB2CHRNA4DRD1MEN1ALDH1A1 | |
| SCHEMBL2895317 | 0.77 | ALOX15 (0.39) | CHRNB2CHRNA4DRD1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323062-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | Novartis AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| EP-4143194-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |
| WO-2022219546-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | NOVARTIS AG (CH) | 2022-10-20 | — | — | WO | disclosed |