SCHEMBL28504175

SCHEMBL28504175

Fc1cc(Br)c2c(c1)C=NCC2

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 1/20 0.30
CHRNA3 P32297 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17103890 0.81 MAOA (0.30)
SCHEMBL30564264 0.70 KDM1A (0.30)
SCHEMBL16964130 0.70 CHRNB4 (0.30) CHRNB4CHRNA3
SCHEMBL30834466 0.69 TRPA1 (0.44)
SCHEMBL31359422 0.67
SCHEMBL2972520 0.67
SCHEMBL20571518 0.67 KDM1A (0.30)
SCHEMBL17103960 0.67
SCHEMBL29733099 0.67 NOS3 (0.30)
SCHEMBL9572969 0.65 ADRA2A (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624035-B2 Compounds for targeted protein degradation AMPHISTA THERAPEUTICS LIMITED (GB) 2026-05-12 US disclosed
US-20260070904-A1 COMPOUNDS FOR TARGETED PROTEIN DEGRADATION AMPHISTA THERAPEUTICS LIMITED (GB) 2026-03-12 US disclosed
CN-107108583-B Indole carboxamide compounds useful as kinase inhibitors 百时美施贵宝公司 2020-11-13 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260070904-A1 COMPOUNDS FOR TARGETED PROTEIN DEGRADATION BRD9, BRWD1, BRD1 CHRNB4 3909/4885CHRNA3 3896/4885
US-12624035-B2 Compounds for targeted protein degradation BRD9, BRD1, BRD3 CHRNB4 3584/4885CHRNA3 3302/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.