Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | TXNRD1 | Q16881 | 3/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296081 | 0.83 | TBXAS1 (0.35) | KDM4ETAAR1TXNRD1 | |
| SCHEMBL4681643 | 0.83 | TBXAS1 (0.35) | KDM4ETAAR1TXNRD1 | |
| SCHEMBL7288664 | 0.82 | TBXAS1 (0.33) | KDM4EHTR1ATAAR1TXNRD1 | |
| SCHEMBL4681647 | 0.81 | CA2 (0.40) | EPHX2KDM4E | |
| SCHEMBL7296085 | 0.81 | CA2 (0.40) | EPHX2KDM4E | |
| SCHEMBL2010779 | 0.81 | ALDH1A1 (0.39) | CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL7288670 | 0.81 | CA2 (0.40) | KDM4ETAAR1TXNRD1 | |
| Isophthalic Acid SCHEMBL28033549 | 0.78 | PTPN11 (0.40) | — | |
| SCHEMBL4682203 | 0.78 | TAAR1 (0.33) | HTR1ATAAR1TXNRD1 | |
| SCHEMBL4682206 | 0.77 | CA2 (0.36) | HTR1ATAAR1TXNRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751156-B1 | 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO(3,2-B)INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS | TIBOTEC PHARM LTD (IE) | 2010-09-15 | — | — | EP | disclosed |
| US-20100029635-A1 | 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS | KESTELEYN BART RUDOLF ROMANIE | 2010-02-04 | — | — | US | disclosed |
| US-7622582-B2 | Derivatives of 1-phenyl-benzofuro[3,2]pyridin-2(1H)-one | TIBOTEC BVBA (BE) | 2009-11-24 | — | — | US | disclosed |
| US-7622581-B2 | 6,7,8,9-substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2009-11-24 | — | — | US | disclosed |
| US-7615639-B2 | 1-pyridyl-benzofuro[3,2-b]pyridin-2(1H)-ones | TIBOTEC PHARMACEUTICALS, LTD. (IE) | 2009-11-10 | — | — | US | disclosed |
| US-20070265295-A1 | 1-Heterocyclyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2007-11-15 | — | — | US | disclosed |
| US-20070238727-A1 | 5-Substituted 1-Phenyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones and Analogs as Anti-Virals | TIBOTEC BVBA (BE) | 2007-10-11 | — | — | US | disclosed |
| US-20070213320-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC BVBA (BE) | 2007-09-13 | — | — | US | disclosed |
| US-20070167434-A1 | 6,7,8,9-Substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | TIBOTEC BVBA (BE) | 2007-07-19 | — | — | US | disclosed |
| EP-1758911-A1 | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | Tibotec Pharmaceuticals Ltd. (IE) | 2007-03-07 | — | — | EP | disclosed |
| EP-1751165-A1 | 4-SUBSTITUTED 1,5-DIHYDRO-PYRIDO(3,2-B)INDOL-2-ONES | Tibotec Pharmaceuticals Ltd. (IE) | 2007-02-14 | — | — | EP | disclosed |
| EP-1751154-A1 | 5-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO[3,2-B] INDOL-2-ONES AND ANALOGS AS ANTI-VIRALS | Tibotec Pharmaceuticals Ltd. (IE) | 2007-02-14 | — | — | EP | disclosed |
| EP-1751156-A1 | 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO(3,2-B)INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS | Tibotec Pharmaceuticals Ltd. (IE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005111035-A1 | 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-11-24 | — | — | WO | disclosed |
| WO-2005111034-A1 | 5-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO’3,2-B! INDOL-2-ONES AND ANALOGS AS ANTI-VIRALS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-11-24 | — | — | WO | disclosed |
| WO-2005111044-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-11-24 | — | — | WO | disclosed |
| WO-2005111047-A1 | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213320-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | NR2C2, CYP4B1, OXER1 | EPHX2 188/4885CYP1A2 14/4885CYP3A4 15/4885 |
| US-20070265295-A1 | 1-Heterocyclyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones | CBR1, HRH4, CYP4B1 | EPHX2 97/4885CYP1A2 12/4885CYP3A4 20/4885 |
| US-20100029635-A1 | 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS | HRH4, CBR1, HRH2 | EPHX2 192/4885CYP1A2 19/4885CYP3A4 11/4885 |
| US-20070167434-A1 | 6,7,8,9-Substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | HRH4, CBR1, HRH2 | EPHX2 191/4885CYP1A2 19/4885CYP3A4 12/4885 |
| US-20070238727-A1 | 5-Substituted 1-Phenyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones and Analogs as Anti-Virals | NR5A2, NR5A1, NR4A1 | EPHX2 587/4885CYP1A2 61/4885CYP3A4 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.