Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854702 | 0.81 | USP2 (0.42) | LMNAGFERUSP2TSHRMAPK1 | |
| SCHEMBL2856206 | 0.77 | ALDH1A1 (0.48) | LMNAGFERUSP2GPR142MAPK1 | |
| SCHEMBL2854493 | 0.76 | GPR142 (0.56) | LMNAGFERUSP2GPR142MAPK1 | |
| SCHEMBL14818747 | 0.73 | MAPK1 (0.78) | LMNAGFERUSP2TSHRMAPK1 | |
| SCHEMBL2755872 | 0.72 | USP2 (0.60) | LMNAGFERUSP2TSHRMAPK1 | |
| SCHEMBL2857154 | 0.72 | KMT2A (0.55) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL16565835 | 0.72 | USP2 (0.65) | LMNAGFERUSP2TSHRMAPK1 | |
| SCHEMBL2092776 | 0.71 | USP2 (0.59) | LMNAGFERUSP2TSHRMAPK1 | |
| SCHEMBL19226522 | 0.71 | USP2 (0.59) | LMNAGFERUSP2TSHRMAPK1 | |
| SCHEMBL17888452 | 0.71 | MMP13 (0.60) | LMNAGFERUSP2TSHRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |