Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28515277 | 0.85 | EPAS1 (0.46) | CDK4CDK2MEN1KMT2AEPAS1 | |
| SCHEMBL28516641 | 0.83 | MAPK10 (0.48) | CDK4CDK2MEN1KMT2AEPAS1 | |
| SCHEMBL28516643 | 0.76 | FGFR4 (0.60) | MEN1KMT2AMAPK1ALDH1A1L3MBTL1 | |
| SCHEMBL16654477 | 0.74 | ABCG2 (0.46) | CDK4CDK2MEN1KMT2AEPAS1 | |
| SCHEMBL16654895 | 0.74 | MAPT (0.55) | CDK4CDK2MEN1KMT2AEPAS1 | |
| SCHEMBL28523405 | 0.74 | EPAS1 (0.52) | CDK4CDK2MEN1KMT2AEPAS1 | |
| SCHEMBL28613042 | 0.73 | EGFR (0.50) | CDK4CDK2MEN1KMT2AEPAS1 | |
| SCHEMBL7778637 | 0.72 | ALDH1A1 (0.54) | MEN1KMT2AEPAS1EGFRMAPT | |
| SCHEMBL2261930 | 0.72 | CYP1A2 (0.60) | CDK2MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL29889652 | 0.72 | CYP1A2 (0.60) | CDK2MEN1KMT2AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112341431-A | Heterocyclic compounds as FGFR4 inhibitors | 齐鲁制药有限公司 | 2021-02-09 | — | — | CN | disclosed |