SCHEMBL2852231

SCHEMBL2852231

CO/C=C(/C(=O)O)c1ccccc1Oc1cc(Oc2ccccc2F)ncn1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAF1 P04049 2/20 0.37
CHRM2 P08172 1/20 0.37
CHRM4 P08173 1/20 0.37
CHRM5 P08912 1/20 0.37
CHRM1 P11229 1/20 0.37
CHRM3 P20309 1/20 0.37
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
MAP4K4 O95819 1/20 0.36
MRGPRX1 Q96LB2 1/20 0.36
GCK P35557 1/20 0.36
MAPT P10636 2/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
CXCL8 P10145 1/20 0.36
FFAR4 Q5NUL3 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ALDH1A1 P00352 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
KDR P35968 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2852235 1.00 RAF1 (0.37) RAF1CHRM2CHRM4CHRM5CHRM1
SCHEMBL29360421 1.00 RAF1 (0.37) RAF1CHRM2CHRM4CHRM5CHRM1
SCHEMBL29362167 0.93 CHRM4 (0.36) CHRM4KMT2AMEN1GCKFFAR4
SCHEMBL2849778 0.93 CHRM4 (0.36) CHRM4KMT2AMEN1GCKFFAR4
SCHEMBL2849774 0.93 CHRM4 (0.36) CHRM4KMT2AMEN1GCKFFAR4
SCHEMBL29359104 0.90 MAPK8 (0.39) RAF1CHRM2CHRM4CHRM5CHRM1
SCHEMBL203515 0.90 MAPK8 (0.39) RAF1CHRM2CHRM4CHRM5CHRM1
SCHEMBL8958973 0.90 MAPK8 (0.39) RAF1CHRM2CHRM4CHRM5CHRM1
SCHEMBL2852233 0.89 MRGPRX1 (0.40) RAF1CHRM2CHRM4CHRM5CHRM1
SCHEMBL2857202 0.88 SMN1; SMN2 (0.42) RAF1KMT2AMEN1MAP4K4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 315 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12043600-B2 Microbiocidal compounds SYNGENTA CROP PROTECTION AG (CH) 2024-07-23 US disclosed
US-12012399-B2 Microbiocidal quinoline dihydro-(thiazine)oxazine derivatives SYNGENTA PARTICIPATIONS AG (CH) 2024-06-18 US disclosed
CN-114340374-B Sowing device and method for treating seeds during planting 先正达参股股份有限公司 2024-06-11 CN disclosed
US-20240041028-A1 DELIVERY SYSTEM FOR PLANT PROTECTION OMYA INTERNATIONAL AG (CH) 2024-02-08 US disclosed
US-11882834-B2 Microbiocidal thiazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2024-01-30 US disclosed
EP-4271185-A1 DELIVERY SYSTEM FOR PLANT PROTECTION Omya International AG (CH) 2023-11-08 EP disclosed
CN-111303116-B Microbiocidal heterobicyclic derivatives 先正达参股股份有限公司 2023-10-10 CN disclosed
US-11744246-B2 Preparation of mammalian oocyte for fertilization via a soluble human PH20 hyaluronidase polypeptide SYNGENTA PARTICIPATIONS AG (CH) 2023-09-05 US disclosed
EP-3717479-B1 MICROBIOCIDAL THIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2023-07-05 EP disclosed
EP-3941898-B1 FUNGICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-06-07 EP disclosed
US-20050187215-A1 synergistic mixture of certain previously disclosed cyclic ketoenols and agonists or antagonists of nicotinic acetylcholine receptors BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2005-08-25 US disclosed
US-6893651-B1 Synergistic combination of cyclic ketoenol with agonists or antagonists of nicotinic acetylcholine receptors; protecting plants BAYER AKTIENGESELLSCHAFT (DE) 2005-05-17 US disclosed
US-6846777-B2 Synergistic biocidal composition THOR GMBH (DE) 2005-01-25 US disclosed
US-6686387-B2 SPINOSYNS AND AGONISTS OR ANTAGONISTS OF NICOTINIC ACETYLCHOLINE RECEPTORS; PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2004-02-03 US disclosed
US-20030199490-A1 Synergistic biocidal composition THOR GMBH (DE) 2003-10-23 US disclosed
US-20030092641-A1 Synergistic insecticidal mixtures DOW AGROSCIENCES LLC 2003-05-15 US disclosed
US-6444667-B1 OF SPINOSYNS AND AGONISTS OR ANTAGONISTS OF NICOTINIC ACETYLCHOLINE RECEPTORS FOR PROTECTING PLANTS BAYER AKTIENGESELLSCHAFT (DE) 2002-09-03 US disclosed
US-5990043-A COMPRISES AT LEAST ONE INSECTICIDE SELECTED FROM TRIFLUMURON, FLUFENOXURON, FLUCYCLOXURON, HEXAFLUMURON, AND OTHERS; A CARRIER AND BINDER; PROTECTS ITEMS SUCH AS SHIP HULLS IN BRACKISH OR SEAWATER FROM BARNICLE INFESTATIONS BAYER AKTIENGESELLSCHAFT (DE) 1999-11-23 US disclosed
US-5972971-A WOOD PRESERVATIVE CONSISTS OF A MIXTURE OF METACONAZOLE OR AN ACID ADDITION SALT OR METAL COMPLEX AND IMIDACLOPRID OR SALT OR METAL COMPLEX BAYER AKTIENGESELLSCHAFT (DE) 1999-10-26 US disclosed
US-5466693-A FOE USE IN THE CULTIVATION OF RICE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1995-11-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030092641-A1 Synergistic insecticidal mixtures CHRM3, ACHE, CHRM2 RAF1 4294/4885CHRM2 3/4885CHRM4 9/4885
US-12043600-B2 Microbiocidal compounds MPO, MSR1, PRF1 RAF1 3717/4885CHRM2 543/4885CHRM4 734/4885
US-11882834-B2 Microbiocidal thiazole derivatives MSR1, TLR1, IFNG RAF1 3875/4885CHRM2 909/4885CHRM4 1096/4885
US-12012399-B2 Microbiocidal quinoline dihydro-(thiazine)oxazine derivatives TLR1, TLR5, IDO1 RAF1 3144/4885CHRM2 2702/4885CHRM4 2608/4885
US-20050187215-A1 synergistic mixture of certain previously disclosed cyclic ketoenols and agonists or antagonists of nicotinic acetylcholine receptors CHRNG, CHRM3, CHRNE RAF1 2683/4885CHRM2 11/4885CHRM4 14/4885
US-11744246-B2 Preparation of mammalian oocyte for fertilization via a soluble human PH20 hyaluronidase polypeptide PHF20, FUCA1, ZP1 RAF1 2889/4885CHRM2 2968/4885CHRM4 3687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.