Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.33 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.33 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.33 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858110 | 0.83 | KDM4E (0.44) | MAPTGPR6MALT1POLBSMN1; SMN2 | |
| SCHEMBL2859506 | 0.81 | MAPT (0.45) | MAPTGPR6ACHEARTRPC1 | |
| SCHEMBL2852244 | 0.80 | MAPT (0.48) | MAPTGPR6ACHETRPC1TRPC3 | |
| SCHEMBL2850631 | 0.78 | P2RX1 (0.41) | MAPTMALT1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2848317 | 0.77 | MAPT (0.46) | MAPTGPR6ACHETRPC1TRPC3 | |
| SCHEMBL2850421 | 0.77 | CLK2 (0.51) | MAPTTRPV1POLBSMN1; SMN2KDM4E | |
| SCHEMBL2854626 | 0.77 | MAPT (0.40) | MAPTGPR6ACHEP2RX7TRPC1 | |
| SCHEMBL2854992 | 0.76 | L3MBTL1 (0.43) | MAPTGPR6ACHESMN1; SMN2ALDH1A1 | |
| SCHEMBL2850712 | 0.76 | MAPT (0.41) | MAPTGPR6MALT1ACHEP2RX7 | |
| SCHEMBL2853065 | 0.76 | NR3C1 (0.46) | MAPTTRPC1TRPC3STIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |