SCHEMBL28528329

SCHEMBL28528329

Cc1ccc([PH](=O)C(=O)c2c(C)cc(C)cc2C)c(C)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
KMT2A Q03164 6/20 0.36
MEN1 O00255 4/20 0.36
SMN1; SMN2 Q16637 3/20 0.35
HPGD P15428 2/20 0.35
KDM4E B2RXH2 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
LMNA P02545 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
MCOLN3 Q8TDD5 1/20 0.35
ALDH1A1 P00352 1/20 0.33
HTT P42858 1/20 0.33
EGFR P00533 1/20 0.33
ERBB2 P04626 1/20 0.33
TAS1R3 Q7RTX0 2/20 0.33
TAS1R1 Q7RTX1 2/20 0.33
TAS1R2 Q8TE23 2/20 0.33
GAA P10253 1/20 0.33
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17424000 0.88 TDP1 (0.35) TP53TDP1KMT2AMEN1SMN1; SMN2
SCHEMBL28200325 0.84 LMNA (0.36) KMT2AMEN1SMN1; SMN2HPGDKDM4E
SCHEMBL20360103 0.80 KMT2A (0.37) TP53TDP1KMT2AMEN1SMN1; SMN2
SCHEMBL29044846 0.78 RAPGEF4 (0.37) TP53KMT2AMEN1SMN1; SMN2HPGD
SCHEMBL4244313 0.77 TAS1R3 (0.38) KMT2AMEN1SMN1; SMN2HPGDKDM4E
SCHEMBL562789 0.77 TDP1 (0.44) TP53TDP1KMT2AMEN1SMN1; SMN2
SCHEMBL28907049 0.76 USP2 (0.37) KMT2AMEN1SMN1; SMN2HPGDKDM4E
SCHEMBL29877185 0.76 LMNA (0.39) KMT2AMEN1SMN1; SMN2HPGDKDM4E
SCHEMBL28049109 0.76 ALDH1A1 (0.40) TP53KMT2AMEN1SMN1; SMN2KDM4E
SCHEMBL82366 0.75 LMNA (0.40) KMT2AMEN1SMN1; SMN2HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112279940-A Acylphosphine photoinitiator and preparation method thereof 山东科技大学 2021-01-29 CN disclosed