SCHEMBL28530645

SCHEMBL28530645

CCOC(=O)c1ccc(S(C)(=O)=O)c(C2=NOCC2)c1C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.35
NPC1 O15118 1/20 0.35
CASP3 P42574 1/20 0.35
RAB9A P51151 1/20 0.35
ATM Q13315 1/20 0.35
SENP8 Q96LD8 1/20 0.35
SENP7 Q9BQF6 1/20 0.35
SENP6 Q9GZR1 1/20 0.35
KDM4E B2RXH2 4/20 0.34
MAPT P10636 2/20 0.34
KMT2A Q03164 1/20 0.34
ALDH1A1 P00352 2/20 0.34
LMNA P02545 2/20 0.34
PKM P14618 1/20 0.34
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA7 P43166 1/20 0.34
CA9 Q16790 1/20 0.34
CA14 Q9ULX7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4699882 0.88 LMNA (0.33) NPC1CASP3RAB9ASENP8SENP7
SCHEMBL29429101 0.84 GABRP (0.31) KDM4EKMT2AALDH1A1LMNA
SCHEMBL4698411 0.84 GABRP (0.31) KDM4EKMT2AALDH1A1LMNA
SCHEMBL4703228 0.83
SCHEMBL30608210 0.83
SCHEMBL29102561 0.81 ALDH1A1 (0.38) TSHRNPC1CASP3RAB9AATM
SCHEMBL702111 0.77 SMN1; SMN2 (0.32) RAB9AALDH1A1LMNA
SCHEMBL30833820 0.77 NPC1 (0.35) TSHRNPC1CASP3RAB9AATM
SCHEMBL30833819 0.77 NPC1 (0.35) TSHRNPC1CASP3RAB9AATM
SCHEMBL13415355 0.76 SMN1; SMN2 (0.35) NPC1RAB9AMAPTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107652247-B Preparation method of 2-methyl-3- [4, 5-dihydroisoxazole ] -4-methylsulfonyl ethyl benzoate 黄河三角洲京博化工研究院有限公司 2020-11-03 CN claimed
CN-117986198-A Preparation method of herbicide intermediate 帕潘纳(北京)科技有限公司 2024-05-07 CN disclosed
CN-116947837-A Topramezone intermediate and preparation method thereof 帕潘纳(北京)科技有限公司 2023-10-27 CN disclosed
CN-107652247-B Preparation method of 2-methyl-3- [4, 5-dihydroisoxazole ] -4-methylsulfonyl ethyl benzoate 黄河三角洲京博化工研究院有限公司 2020-11-03 CN disclosed