Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2860106 | 0.88 | KLKB1 (0.52) | ALDH1A1SMN1; SMN2NPC1RAB9AKLKB1 | |
| SCHEMBL2859721 | 0.88 | KLKB1 (0.49) | LMNAHPGDALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL2852927 | 0.85 | KLKB1 (0.50) | HPGDALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2852329 | 0.82 | TAAR1 (0.49) | ALDH1A1SMN1; SMN2NPC1RAB9AKLKB1 | |
| SCHEMBL2848515 | 0.82 | LMNA (0.50) | LMNAHPGDALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2861622 | 0.82 | EPHX1 (0.60) | LMNAHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL2852519 | 0.81 | TAAR1 (0.59) | ALDH1A1SMN1; SMN2NPC1RAB9AKLKB1 | |
| SCHEMBL2858761 | 0.80 | LMNA (0.76) | LMNAHPGDSMN1; SMN2KLKB1L3MBTL1 | |
| SCHEMBL2848393 | 0.79 | TAAR1 (0.48) | ALDH1A1SMN1; SMN2NPC1RAB9AKLKB1 | |
| SCHEMBL2859353 | 0.79 | TAAR1 (0.66) | LMNAHPGDALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |