SCHEMBL2853152

SCHEMBL2853152

C=C(C#N)COc1cc(C)cnc1Cl

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.33
ATM Q13315 1/20 0.33
ALDH1A1 P00352 3/20 0.33
HPGD P15428 2/20 0.33
KDM4E B2RXH2 1/20 0.33
TP53 P04637 1/20 0.31
RAB9A P51151 1/20 0.31
PTGDR2 Q9Y5Y4 1/20 0.30
LMNA P02545 1/20 0.30
HTT P42858 1/20 0.30
CYP1A2 P05177 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2853131 0.84 ALDH1A1 (0.32) ALDH1A1HPGDKDM4E
SCHEMBL2858821 0.78 ALDH1A1 (0.50) ALDH1A1HPGDKDM4EPTGDR2CYP1A2
SCHEMBL2851115 0.74 LMNA (0.40) NPC1ATMHPGDKDM4ETP53
SCHEMBL17696409 0.72 GRM5 (0.44) ATMALDH1A1HPGDKDM4ERAB9A
SCHEMBL2853209 0.71 L3MBTL1 (0.38) ALDH1A1HPGDKDM4ELMNAHTT
SCHEMBL17460034 0.70 GAA (0.42) ALDH1A1HPGDKDM4EHTT
SCHEMBL14474332 0.68 SMN1; SMN2 (0.42) NPC1ATMALDH1A1HPGDTP53
SCHEMBL13928210 0.68 CHRNB2 (0.43) NPC1ALDH1A1HPGDKDM4ERAB9A
SCHEMBL11074611 0.66 WDR5 (0.50) NPC1ALDH1A1HPGDKDM4ELMNA
SCHEMBL2851700 0.66 EGFR (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1924558-B1 AN ANTIMALARIAL BAYLIS-HILLMAN ADDUCTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL SCIENT IND RES (IN) 2010-01-13 EP claimed
EP-1924558-A1 AN ANTIMALARIAL BAYLIS-HILLMAN ADDUCTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2008-05-28 EP claimed
WO-2007032016-A1 AN ANTIMALARIAL BAYLIS-HILLMAN ADDUCTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2007-03-22 WO claimed
EP-1924558-B1 AN ANTIMALARIAL BAYLIS-HILLMAN ADDUCTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL SCIENT IND RES (IN) 2010-01-13 EP disclosed
EP-1924558-A1 AN ANTIMALARIAL BAYLIS-HILLMAN ADDUCTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2008-05-28 EP disclosed
WO-2007032016-A1 AN ANTIMALARIAL BAYLIS-HILLMAN ADDUCTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2007-03-22 WO disclosed