Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MST1R | Q04912 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857584 | 0.93 | RAB9A (0.45) | SMN1; SMN2MAPTPOLBALDH1A1HTT | |
| SCHEMBL2860786 | 0.87 | MAPT (0.49) | SMN1; SMN2MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2853255 | 0.86 | HSP90AA1 (0.48) | SMN1; SMN2MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2857574 | 0.84 | MAPT (0.50) | SMN1; SMN2MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2850871 | 0.84 | NPC1 (0.51) | SMN1; SMN2MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2856355 | 0.83 | RAB9A (0.52) | SMN1; SMN2MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2850763 | 0.82 | MAPT (0.48) | SMN1; SMN2MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2850858 | 0.82 | KDR (0.48) | SMN1; SMN2MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2850725 | 0.81 | MAPT (0.54) | SMN1; SMN2MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2852552 | 0.81 | MEN1 (0.51) | SMN1; SMN2MAPTPOLBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |