Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18305024 | 1.00 | ALDH1A1 (0.38) | ALDH1A1MAPTSMN1; SMN2MAPK1LMNA | |
| SCHEMBL28082067 | 0.87 | KMT2A (0.42) | ALDH1A1HPGDSRD5A2MEN1KMT2A | |
| SCHEMBL30806384 | 0.87 | KMT2A (0.42) | ALDH1A1HPGDSRD5A2MEN1KMT2A | |
| SCHEMBL28082066 | 0.87 | KMT2A (0.42) | ALDH1A1HPGDSRD5A2MEN1KMT2A | |
| SCHEMBL30806393 | 0.87 | KMT2A (0.42) | ALDH1A1HPGDSRD5A2MEN1KMT2A | |
| SCHEMBL20138230 | 0.87 | TSHR (0.40) | ALDH1A1MAPTSMN1; SMN2MAPK1LMNA | |
| SCHEMBL18304994 | 0.85 | ALDH1A1 (0.38) | ALDH1A1MAPTMAPK1HPGDSRD5A2 | |
| SCHEMBL28529013 | 0.85 | ALDH1A1 (0.38) | ALDH1A1MAPTMAPK1HPGDSRD5A2 | |
| SCHEMBL31750457 | 0.84 | KMT2A (0.45) | ALDH1A1MAPTMAPK1HPGDKDM4E | |
| SCHEMBL532854 | 0.82 | XDH (0.43) | ALDH1A1MAPTSMN1; SMN2KDM4ESRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107873031-B | Benzoxazinone derivatives and analogs thereof as modulators of TNF activity | UCB生物制药私人有限公司 | 2021-03-12 | — | — | CN | disclosed |