Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | KYNU | Q16719 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16862569 | 1.00 | KDM4E (0.33) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL16862495 | 0.87 | MAPT (0.49) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL20338032 | 0.87 | MAPT (0.49) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL7032142 | 0.85 | MME (0.36) | THRBKYNUITGB3ITGA2BTAS1R3 | |
| SCHEMBL7328622 | 0.84 | TAS1R3 (0.46) | SMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL23781491 | 0.83 | CHRNB2 (0.35) | — | |
| SCHEMBL20338029 | 0.83 | CASP1 (0.36) | KYNUITGB3ITGA2BATM | |
| SCHEMBL17841822 | 0.83 | CASP1 (0.36) | KYNUITGB3ITGA2BATM | |
| SCHEMBL16862539 | 0.83 | CHRNB2 (0.35) | — | |
| SCHEMBL16862526 | 0.81 | ITGB3 (0.32) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109310781-B | Specific antibody-drug-conjugates (ADC) having a KSP inhibitor and an anti-CD 123-antibody | 拜耳制药股份公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-110312533-B | Prodrugs of cytotoxic active agents having enzymatically cleavable groups | 拜耳公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-116059390-A | Prodrugs of cytotoxic actives with enzymatically cleavable groups | 拜耳制药股份公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-110072556-B | Specific Antibody Drug Conjugates (ADC) with KSP inhibitors | 拜耳制药股份公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-114917361-A | Antibody Drug Conjugates (ADC) and antibody prodrug conjugates (APDC) with enzyme cleavable groups | 拜耳医药股份有限公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-107635586-B | Antibody-drug conjugates (ADC) of KSP inhibitors with aglycosylated anti-TWEAKR antibodies | 拜耳医药股份有限公司 | 2021-09-24 | — | — | CN | disclosed |
| CN-106163568-B | Antibody Drug Conjugates (ADC) containing spindle Kinesin (KSP) | 拜耳制药股份公司 | 2021-03-23 | — | — | CN | disclosed |