Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9567942 | 0.85 | F9 (0.57) | PLAUF9F10 | |
| Hydrochloric Acid SCHEMBL9432197 | 0.83 | PLAU (0.58) | PLAUF9F10 | |
| SCHEMBL9431295 | 0.80 | ALDH1A1 (0.60) | DYRK1AGSK3AGSK3BAURKBRPS6KB1 | |
| SCHEMBL28540745 | 0.78 | KDM4E (0.61) | LIMK1DYRK1ACHEK1AURKADAPK3 | |
| SCHEMBL347544 | 0.77 | BCL2L1 (0.69) | LIMK1DYRK1ACHEK1AURKADAPK3 | |
| SCHEMBL29366392 | 0.77 | BCL2L1 (0.69) | LIMK1DYRK1ACHEK1AURKADAPK3 | |
| SCHEMBL28744296 | 0.76 | KDM4E (0.59) | MAPK1CNR2F9KDM4EGLA | |
| Hydrochloric Acid SCHEMBL2196804 | 0.75 | BCL2L1 (0.67) | LIMK1DYRK1ACHEK1AURKADAPK3 | |
| SCHEMBL28162040 | 0.74 | DYRK1A (0.51) | LIMK1DYRK1ACHEK1AURKADAPK3 | |
| SCHEMBL17934651 | 0.73 | ALDH1A1 (0.48) | MAPTHPGDTSHRHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108727416-B | Tricyclic heteroaromatic amide derivative and preparation and application thereof | 北京大学 | 2021-03-09 | — | — | CN | disclosed |