SCHEMBL29366392

SCHEMBL29366392

NC(=O)c1cc2ccccc2s1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.69
SLC9A1 P19634 2/20 0.67
HDAC3 O15379 1/20 0.65
HDAC4 P56524 1/20 0.65
HDAC1 Q13547 1/20 0.65
HDAC7 Q8WUI4 1/20 0.65
HDAC2 Q92769 1/20 0.65
HDAC10 Q969S8 1/20 0.65
HDAC11 Q96DB2 1/20 0.65
HDAC8 Q9BY41 1/20 0.65
HDAC6 Q9UBN7 1/20 0.65
HDAC9 Q9UKV0 1/20 0.65
HDAC5 Q9UQL6 1/20 0.65
DYRK1A Q13627 2/20 0.59
CHEK1 O14757 1/20 0.59
AURKA O14965 1/20 0.59
DAPK3 O43293 1/20 0.59
PRKD3 O94806 1/20 0.59
MAP4K4 O95819 1/20 0.59
PAK4 O96013 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL347544 1.00 BCL2L1 (0.69) BCL2L1SLC9A1HDAC3HDAC4HDAC1
Hydrochloric Acid SCHEMBL2196804 0.98 BCL2L1 (0.67) BCL2L1SLC9A1HDAC3HDAC4HDAC1
SCHEMBL28162040 0.85 DYRK1A (0.51) BCL2L1SLC9A1HDAC3HDAC4HDAC1
SCHEMBL8958420 0.85 BCL2L1 (0.65) BCL2L1SLC9A1HDAC3HDAC4HDAC1
SCHEMBL31356465 0.83 BCL2L1 (0.74) BCL2L1SLC9A1HDAC3HDAC4HDAC1
SCHEMBL7209477 0.83 BCL2L1 (0.74) BCL2L1SLC9A1HDAC3HDAC4HDAC1
SCHEMBL6321234 0.83 BCL2L1 (0.74) BCL2L1SLC9A1HDAC3HDAC4HDAC1
SCHEMBL28162038 0.83 DYRK1A (0.50) BCL2L1SLC9A1HDAC3HDAC4HDAC1
Tetrazole SCHEMBL6927480 0.82 SLC9A1 (0.49) BCL2L1SLC9A1HDAC3HDAC4HDAC1
SCHEMBL4070224 0.82 BCL2L1 (0.61) BCL2L1SLC9A1HDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119707941-A Quinolinone compound, preparation method and application thereof 苏州旺山旺水生物医药股份有限公司 2025-03-28 CN claimed
CN-114450275-B Heteroaryl aminopyridine alcohol derivatives and pharmaceutical composition for preventing or treating autoimmune diseases comprising the same as active ingredient 因诺沃治疗有限公司 2024-11-19 CN claimed
EP-4416268-A1 METHODS FOR PRODUCING CARTILAGE AND BONES Murdoch Children's Research Institute (AU) 2024-08-21 EP claimed
US-20230133600-A1 PHARMACEUTICAL USE OF KETOAMIDE-BASED COMPOUND SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2023-05-04 US claimed
WO-2023060322-A1 METHODS FOR PRODUCING CARTILAGE AND BONES MURDOCH CHILDREN'S RESEARCH INSTITUTE (AU) 2023-04-20 WO claimed
EP-3911646-B1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS FONDAZIONE ST ITALIANO TECNOLOGIA (IT) 2023-03-01 EP claimed
EP-4098258-A1 PHARMACEUTICAL USE OF KETOAMIDE-BASED COMPOUND Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) 2022-12-07 EP claimed
US-12636275-B2 Pharmaceutical use of ketoamide-based compound SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2026-05-26 US disclosed
WO-2026107062-A1 STAT6 DEGRADERS AND USES THEREOF RECLUDIX PHARMA, INC. (US) 2026-05-21 WO disclosed
EP-4680255-A1 METHODS FOR PRODUCING STABLE HUMAN CHONDROCTYES AND THEIR USE FOR PROMOTING CARTILLAGE GROWTH AND REPAIR The United States of America, as represented by the Secretary, Department of Health and Human Services (US) 2026-01-21 EP disclosed
EP-4561991-A1 NOVEL HETEROCYCLES AS SPLA2-X INHIBITORS Cayman Chemical Company, Inc. (US) 2025-06-04 EP disclosed
US-20250136570-A1 HDAC INHIBITORS AND THERAPEUTIC USE THEREOF TANGO THERAPEUTICS, INC. 2025-05-01 US disclosed
EP-4532699-A1 TRIPLE TISSUE CULTURE FUSION IMBA-Institut für Molekulare Biotechnologie GmbH (AT) 2025-04-09 EP disclosed
EP-4098258-A1 PHARMACEUTICAL USE OF KETOAMIDE-BASED COMPOUND Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) 2022-12-07 EP disclosed
CN-115443129-A KCNT1 inhibitors and methods of use 普拉西斯精密医药公司 2022-12-06 CN disclosed
CN-110114353-B Benzo [ b ] thiophene amide derivative and application thereof 山东大学 2022-04-22 CN disclosed
CN-110114353-B Benzo [ b ] thiophene amide derivative and application thereof 山东大学 2022-04-22 CN disclosed
US-20220112177-A1 KETOAMIDE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF FUDAN UNIVERSITY (CN) 2022-04-14 US disclosed
US-20220089584-A1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS ISTITUTO GIANNINA GASLINI (IT) 2022-03-24 US disclosed
CN-113979915-A Dopamine D2Receptor dibit ligand type compound and application 常州大学 2022-01-28 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220112177-A1 KETOAMIDE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF ACE, REN, ACE2 BCL2L1 4751/4885SLC9A1 1027/4885HDAC3 27/4885
US-20230133600-A1 PHARMACEUTICAL USE OF KETOAMIDE-BASED COMPOUND CTSL, CTSV, CTSS BCL2L1 915/4885SLC9A1 1436/4885HDAC3 145/4885
US-20220089584-A1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS CFTR, ABCB11, ABCC5 BCL2L1 2334/4885SLC9A1 91/4885HDAC3 452/4885
US-20250136570-A1 HDAC INHIBITORS AND THERAPEUTIC USE THEREOF HDAC1, HDAC7, HDAC5 BCL2L1 1273/4885SLC9A1 2315/4885HDAC3 9/4885
US-12636275-B2 Pharmaceutical use of ketoamide-based compound CTSV, CTSL, CTSS BCL2L1 873/4885SLC9A1 857/4885HDAC3 103/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.