Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461107 | 0.84 | KDM4E (0.68) | KDM4ERAB9AMAPTNPC1NPSR1 | |
| Hydrochloric Acid SCHEMBL9431489 | 0.83 | KDM4E (0.54) | KDM4ERAB9AMAPTNPC1NPSR1 | |
| SCHEMBL11561435 | 0.83 | MAPT (0.61) | KDM4ERAB9AMAPTNPC1NPSR1 | |
| SCHEMBL9524934 | 0.79 | ALDH1A1 (0.66) | KDM4ERAB9AMAPTNPC1NPSR1 | |
| SCHEMBL28537323 | 0.78 | LIMK1 (0.48) | KDM4EMAPTTDP1L3MBTL1CNR1 | |
| SCHEMBL13295842 | 0.76 | CHRNA1 (0.48) | KDM4ERAB9AMAPTNPC1NPSR1 | |
| SCHEMBL30020347 | 0.75 | KDM4E (0.83) | KDM4ERAB9AMAPTNPC1NPSR1 | |
| SCHEMBL347544 | 0.74 | BCL2L1 (0.69) | RAB9AL3MBTL1CASP3SENP7SENP6 | |
| SCHEMBL29366392 | 0.74 | BCL2L1 (0.69) | RAB9AL3MBTL1CASP3SENP7SENP6 | |
| Hydrochloric Acid SCHEMBL2196804 | 0.73 | BCL2L1 (0.67) | RAB9AL3MBTL1CASP3SENP7SENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108727416-B | Tricyclic heteroaromatic amide derivative and preparation and application thereof | 北京大学 | 2021-03-09 | — | — | CN | disclosed |